California on Wednesday announced the nation’s second confirmed case of the new and apparently more contagious variant of the coronavirus, offering a strong indication that the infection is spreading more widely in the United States.

Gov. Gavin Newsom announced the infection found in Southern California during an online conversation with Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases.

“I don’t think Californians should think that this is odd. It’s to be expected,” Fauci said.

Newsom did not provide any details about the person who was infected.

The announcement came 24 hours after word of the first reported U.S. variant infection emerged in Colorado. That person was identified Wednesday as a Colorado National Guardsman who had been sent to help out at a nursing home struggling with an outbreak. Health officials said a second Guard member may have it too.

The cases triggered a host of questions about how the version circulating in England arrived in the U.S. and whether it is too late to stop it now.

“The virus is becoming more fit, and we’re like a deer in the headlights,” warned Dr. Eric Topol, head of Scripps Research Translational Institute. He noted that the U.S. does far less genetic sequencing of virus samples to discover variants than other developed nations, and thus was probably slow to detect this new mutation.

The two Guard members had been dispatched Dec. 23 to work at the Good Samaritan Society nursing home in the town of Simla, said Dr. Rachel Herlihy, state epidemiologist. They were among six Guard members sent to the home.

Samples from staff and residents at the nursing home are being screened for the variant at the lab, but so far no evidence of it has been found, she said.

Several states are also analyzing suspicious virus samples for the variant, said Dr. Greg Armstrong, who directs genetic sequencing at the Centers for Disease Control and Prevention. He said the CDC is working with a national lab that gets samples from around the country, with results expected within days.