WASHINGTON — President Donald Trump’s big bill in Congress would unleash trillions in tax cuts and slash spending, but also spike deficits by $2.4 trillion over the decade and leave some 10.9 million more people without health insurance, raising the political stakes for the GOP’s signature domestic priority.

Republican leaders in Congress, determined to muscle the sweeping package forward, had little to say after the analysis released Wednesday by the nonpartisan Congressional Budget Office. GOP senators spent more than an hour at the White House in what they called a robust afternoon discussion with Trump.

“We’re committed to making a law that will make the lives of the American people better,” Senate Majority Leader John Thune of South Dakota said afterward. He vowed to “get this done one way or another.”

But Democrats angling to halt the One Big Beautiful Bill Act, named after the president’s own catchphrase, piled on with relentless opposition.

“In the words of Elon Musk, this bill is a ‘disgusting abomination,’ ” said Rep. Brendan Boyle of Pennsylvania, the top Democrat on the House Budget Committee, reviving the billionaire former Trump aide’s criticism of the package.

The analysis comes at a crucial moment as Trump is pushing Congress, where Republicans have majority control, to send the final product to his desk to become law by the Fourth of July. The House passed the bill last month by a single vote, but it’s now slogging through the Senate, where Republicans want a number of significant changes, including those discussed with Trump.

Politics intensifying

Musk blindsided Congress with an all-out assault against the bill this week, leaving House Speaker Mike Johnson rushing to do damage control. The GOP speaker said he called Musk to discuss the criticism, but had not heard back. Musk has threatened to use his political apparatus to go after Republicans in the midterm elections.

Hours later, Musk, whose business interests could be impacted by green energy rollbacks in the bill, implored voters to call their representatives and senators. “Bankrupting America is NOT ok!” he wrote on social media, “KILL the BILL.”

Cuts to health care

The work of the CBO, which for decades has served as the official scorekeeper of legislation in Congress, is closely watched by lawmakers and others seeking to understand the budgetary impacts of the sprawling 1,000-page-plus package.

The bill includes roughly $3.75 trillion in tax cuts — extending the expiring 2017 individual income tax breaks and temporarily adding new ones that Trump campaigned on, including no taxes on tips. The revenue loss would be partially offset by nearly $1.3 trillion in reduced federal spending elsewhere, namely through Medicaid and food assistance.

As a result, some 7.8 million people would no longer have health insurance with changes to Medicaid, including 5.2 million from the proposed new work requirements on those nondisabled adults up to age 65, with some exceptions, the analysis said. Some 1.4 million people who are in the United States without legal status in state-funded health programs would no longer have coverage.

Also, some 400,000 people would lose insurance coverage from the termination of a medical provider tax that key Republicans, including Sen. Josh Hawley of Missouri, want to keep in place to ensure rural hospitals can keep paying their bills.

Republicans argue that their proposals are intended to strengthen Medicaid and other programs by rooting out waste, fraud and abuse. They want the federal funding to go to those who most need health care and other services,