SANTA CLARA >> While this season’s opponents have been set for months, but it’s not too presumptuous to think the 49ers’ 2025 reboot could lift them from the NFC West cellar and back into playoff contention.

They’ll be road warriors early with six away games in the first nine weeks, all in back-to-back sets — at Seattle and New Orleans in Weeks 1 and 2; at Los Angeles and Tampa Bay in Weeks 5 and 6; at Houston and the New York Giants in Weeks 8 and 9.

After three straight seasons of their bye falling in Week 9, this season’s won’t be until Week 14, on Dec. 7. They won’t play on Thanksgiving or Christmas, and three of the final four games are at home, finishing there with Seattle on either Jan. 3 or 4.

Prime-time kickoffs are set for their games at the Rams (Thursday, Oct. 2) and Indianapolis Colts (Monday, Dec. 28), and at home against the Atlanta Falcons (Sunday, Oct. 19), Carolina Panthers (Monday, Nov. 24), and Chicago Bears (Sunday, Dec. 28).

WEEK 1: Sunday, Sept. 7 at Seattle Seahawks (1:05 p.m., FOX) >> The 49ers’ only other season opener in Seattle came 15 years ago, a 31-6 defeat under then-coach Mike Singletary.

WEEK 2: Sunday, Sept. 14 at New Orleans Saints (10 a.m., FOX) >> Which quarterback will the 49ers oppose now that Derek Carr has retired — Danville’s own Jake Haener, second-year prospect Spencer Rattler, rookie Tyler Shough ... or Aaron Rodgers?

WEEK 3: Sunday, Sept. 21vs. Arizona Cardinals (1:25 p.m., FOX) >> The Cardinals are 5-3 at Levi’s Stadium in the Shanahan era, including a 24-23 win last October.

WEEK 4: Sunday, Sept. 28 vs. Jacksonville Jaguars (1:05 p.m. FOX) >> After ousting ex-49ers personnel czar Trent Baalke from their general manager role, they traded up to draft dual threat Travis Hunter at No. 2 overall.

WEEK 5: Thursday, Oct. 2 at Los Angeles Rams (5:15 p.m., Prime Video) >> The 49ers look to reclaim SoFi Stadium as friendly territory, having lost their first regular-season game there last season.

WEEK 6: Sunday, Oct. 12 at Tampa Bay Bucs (10 a.m., CBS) >> Good luck topping the drama of last Nov. 10, when the 49ers won on a walk-off field goal by Jake Moody.

WEEK 7: Sunday, Oct. 19 vs. Atlanta Falcons (5:20 p.m., NBC) >> Washington product Michael Penix returns to the West Coast, presumably as the starter ahead of Shanahan favorite Kirk Cousins.

WEEK 8: Sunday, Oct. 26 at Houston Texans (noon, FOX) >> The NFC West 49ers visit the AFC South 49ers? Reunion vibes will be strong as the Texans boast ex-49ers DeMeco Ryans (coach), linebacker Azeez Al-Shaair, safety Jimmie Ward, guard Laken Tomlinson and offensive tackle Trent Brown (cousin of 49ers rookie Alfred Collins).

WEEK 9: Sunday, Nov. 2 at New York Giants (10 a.m., CBS) >> The New York City marathon is being run this day, so perhaps Christian McCaffrey runs 26.2 miles through the Giants’ defense.

WEEK 10: Sunday, Nov. 9 vs. Los Angeles Rams (1:25 p.m., FOX) >> They’re the reigning NFC West champions for the fourth time over coach Sean McVay’s eight seasons.

WEEK 11: Sunday, Nov. 16 at Arizona Cardinals (1:05 p.m., FOX) >> Yes, last regular-season’s finale saw the host Cardinals bait Jauan Jennings into getting ejected 25 yards shy of his first 1,000-yard season.

WEEK 12: Monday, Nov. 24 vs. Carolina Panthers (5:15 p.m., ESPN) >> The 49ers have never scored more in Shanahan’s eight seasons than the 51-13 win they pinned on the Panthers in their previous visit, in October 2019.

WEEK 13: Sunday, Nov. 30 at Cleveland Browns (10 a.m., CBS) >> The 49ers have not won in Cleveland since their 1984 Super Bowl season.

WEEK 14 >> Sunday, Dec. 7 BYE

WEEK 15: Sunday, Dec. 14 vs. Tennessee Titans (1:25 p.m., FOX) >> How quickly can top-pick quarterback Cam Ward get up to speed under Brian Callahan?

WEEK 16: Monday, Dec. 22 at Indianapolis Colts (5:15 p.m., ESPN) >> Flash back to the last time the 49ers won in Indianapolis, when coach Steve Mariucci’s counterpart, Jim Mora, famously said after the Colts’ 40-21 loss: “Playoffs? Don’t talk about playoffs. You kidding me? Playoffs? I just hope we can win a game.”

WEEK 17: Sunday, Dec. 28 vs. Chicago Bears (5:20 p.m., NBC) >> Caleb Williams, after a rough rookie year, will be tougher to topple behind a fortified offensive line.

WEEK 18: Saturday/Sunday, Jan. 3 or 4 vs. Seattle Seahawks (TBD) >> Geno Smith won’t be rushing past DeVondre Campbell for a last-second score this time at Levi’s Stadium.