BELLEAIR BEACH, Fla. >> Milton strengthened rapidly Monday into a Category 5 hurricane on a path toward Florida, threatening the densely populated Tampa area with a potential direct hit and menacing the same stretch of coastline that was battered by Hurricane Helene less than two weeks ago.

The center of the storm could come ashore Wednesday in the Tampa Bay region, which has not endured a head-on hit by a major hurricane in more than a century. Scientists expect the system to weaken slightly before landfall, though it could retain hurricane strength as it churns across central Florida toward the Atlantic Ocean. That would largely spare other states ravaged by Helene, which killed at least 230 people on its path from Florida to the Appalachian Mountains.

“This is the real deal here with Milton,” Tampa Mayor Jane Castor said at a news conference. “If you want to take on Mother Nature, she wins 100% of the time.”

Florida Gov. Ron DeSantis said Monday that it was imperative that debris from Helene be cleared ahead of Milton’s arrival so the pieces cannot become projectiles.

As evacuation orders were issued, forecasters warned of a possible 8- to 12-foot storm surge (2.4 to 3.6 meters) in Tampa Bay and widespread flooding from 5 to 10 inches (13 to 25 centimeters) of rain in mainland Florida and the Keys, with as much as 15 inches (38 centimeters) in places. The Tampa metro area has a population of more than 3.2 million people.

“It’s a huge population. It’s very exposed, very inexperienced, and that’s a losing proposition,” MIT meteorology professor Kerry Emanuel said. “I always thought Tampa would be the city to worry about most.”

Much of Florida’s west coast was under hurricane and storm surge watches. Florida’s Lake Okeechobee, which often floods during intense storms, was also under a hurricane watch. A hurricane warning was issued for parts of Mexico’s Yucatan state, which expected to get sideswiped.

The compact Milton intensified quickly Monday over the eastern Gulf of Mexico. It had maximum sustained winds of 175 mph (282 kph), the National Hurricane Center said. The storm’s center was about 700 miles (1,126 kilometers) southwest of Tampa at midday, moving east-southeast at 9 mph (15 kph).

The Tampa Bay area is still rebounding from Helene and its powerful surge. Twelve people died there, with the worst damage along a string of barrier islands from St. Petersburg to Clearwater.

In the race to clear away the aftermath from Helene, more than 300 vehicles gathered debris Sunday but encountered a locked landfill gate when they tried to drop it off. State troopers used a rope tied to a pickup truck and busted it open, DeSantis said.

“We don’t have time for bureaucracy and red tape,” DeSantis said.

Lifeguards in Pinellas County, on the peninsula that forms Tampa Bay, removed beach chairs and other items that could take flight in strong winds. Elsewhere, stoves, chairs, refrigerators and kitchen tables waited in heaps to be picked up.

Sarah Steslicki, who lives in Belleair Beach, said she was frustrated more debris had not been collected sooner.

“They’ve screwed around and haven’t picked the debris up, and now they’re scrambling to get it picked up,” Steslicki said Monday morning. “If this one does hit, it’s going to be flying missiles. Stuff’s going to be floating and flying in the air.”