DUBAI, United Arab Emirates >> The United States inserted itself into Israel’s war against Iran by dropping 30,000-pound bombs on a uranium enrichment site early Sunday, raising urgent questions about what remains of Tehran’s nuclear program and how its weakened military might respond.

Iran lashed out at the U.S. for crossing “a very big red line” with its risky decision to launch strikes on three Iranian nuclear sites with missiles and bunker-buster bombs.

“The U.S. has attacked us; what would you do in such a situation? Naturally, they must receive a response to their aggression,” Iranian President Masoud Pezeshkian said during a call with France’s leader, according to the president’s website.

Ali Akbar Velayati, an adviser to Iran’s supreme leader, said any country used by the U.S. to strike Iran “will be a legitimate target for our armed forces,” the state-run IRNA news agency reported.

Amid fears of a wider regional conflict, the Trump administration sent a clear message that it wanted to restart diplomatic talks with Iran. “Let’s meet directly,” Secretary of State Marco Rubio said in an interview with CBS. Defense Secretary Pete Hegseth told reporters that the U.S. “does not seek war.”

But Tehran said the time for diplomacy had passed and that it has the right to defend itself. Iranian Foreign Minister Abbas Araghchi said he would immediately fly to Moscow to coordinate with close ally Russia.

President Donald Trump earlier warned there would be additional strikes if Tehran retaliated against U.S. forces. Tens of thousands of American troops are based in the Middle East. “There will either be peace or there will be tragedy for Iran,” said Trump, who acted without congressional authorization.

The Atomic Energy Organization of Iran confirmed that attacks took place on the Fordo and Natanz enrichment facilities, as well as the Isfahan nuclear site. Both Iran and the U.N. nuclear watchdog said there were no immediate signs of radioactive contamination around the sites.