Isaac Brown ran for a career high 151 yards and a clinching touchdown in the fourth quarter as visiting Louisville beat No. 11 Clemson for the first time, 33-21 on Saturday night.

Cardinals quarterback Tyler Shough somersaulted for a score and Brock Travelstead tied his career high with four field goals as Louisville (6-4, 4-2 Atlantic Coast Conference) qualified for a bowl game and snapped an 0-8 career mark against the Tigers (6-2, 5-1).

The Cardinals also seriously dented Clemson’s hopes of playing for an ACC title and reaching the College Football Playoff. The Tigers were among four undefeated ACC teams when the week began and now must get outside help with the season in its final month.

Shough put the Cardinals ahead for good in the second quarter with a 4-yard burst, finishing with a somersault into the end zone for a 10-7 lead.

Travelstead, who was 9 of 15 on field goals this season, made kicks of 21, 42, 40 and 49 yards to match his career high accomplished twice last season.

NO. 2 GEORGIA 34, FLORIDA 20: Carson Beck threw for 309 yards and two touchdowns to offset three interceptions and the visiting Bulldogs defeated the Gators.

Georgia (7-1, 5-1 Southeastern Conference) won its fourth straight in the series, its longest streak since winning six in a row between 1978 and 1983. The Bulldogs took advantage of Florida’s quarterback woes and a special teams error in this one.

Standout freshman DJ Lagway left the game on a cart in the second quarter with a left hamstring injury and with the Gators (4-4, 2-3) leading 10-3. Without him, it was mostly ugly.

Walk-on Aidan Warner completed 7 of 22 passes for 66 yards, with an interception.

The most significant turnover belonged to the Gators. Punter Jeremy Crawshaw failed to handle Rocco Underwood’s low snap on a 51-yard field goal attempt late in the third. It resulted in a 31-yard loss, setting up Beck’s first TD pass.

NO. 5 MIAMI 53, DUKE 31: Heisman Trophy hopeful Cam Ward threw for 400 yards and five more touchdown passes, three to Xavier Restrepo on a record-setting day for both of them and the host Hurricanes (9-0, 5-0 Atlantic Coast Conference) erased a double-digit deficit for the third time this season to roll past the Blue Devils (6-3, 2-3 ACC).

Ward now has 29 touchdown passes, tying Steve Walsh’s Miami season record set in 1988. A 66-yard scoring grab with 7:36 left was the big history-maker: Restrepo tied Mike Harley’s Miami career reception record with his 182nd, broke Santana Moss’ career receiving yards record with 2,573, and Ward tied Walsh’s TD pass mark for the Hurricanes.

NO. 7 TENNESSEE 28, KENTUCKY 18: Dylan Sampson rushed for 141 yards and two touchdowns to lead the host Volunteers over the Wildcats.

Tight end Miles Kitselman caught six passes for 97 yards and a touchdown for Tennessee (7-1, 4-1 Southeastern Conference) as it kept its College Football playoff hopes alive.

The Wildcats (3-5, 1-6) lost their fourth straight game after five starters were out with injuries. During the game, receiver Barion Brown and quarterback Brock Vandagriff were also hurt.

SOUTH CAROLINA 44, NO. 10 TEXAS A&M 20: LaNorris Sellers ran for 106 yards and threw for 244 more and the host Gamecocks finally knocked off one of the Southeastern Conference’s playoff contenders, beating the Aggies.

South Carolina (5-3, 3-3) took LSU and Alabama to the wire this season before losing. But this time its freshman quarterback and senior transfer Raheim Sanders ran all over Aggies (7-2, 5-1), who came into Saturday allowing just 104.5 yards a game.

Sanders, the all-SEC transfer from Arkansas, rushed for 144 yards and two touchdowns.

TEXAS TECH 23, NO. 11 IOWA STATE 22: Behren Morton drove visiting Texas Tech 71 yards for the winning touchdown with 19 seconds left, and the Red Raiders (6-3, 4-2 Big 12) denied the Cyclones their best start in program history.

Tahj Brooks’s 5-yard touchdown run came after Iowa State (7-1, 4-1) had taken its first lead on Rocco Becht’s 44-yard touchdown pass to Carson Brown with 2:11 to play.

Brooks ran 25 times for 122 yards to go over 4,000 for his career. He has gone over 100 yards in all nine of his games this season.

The Red Raiders (6-3, 4-2 Big 12) got the win after dropping consecutive games to Baylor and TCU.

HOUSTON 24, NO. 17 KANSAS STATE 19: Zeon Chriss threw for 103 yards and a touchdown without an incompletion as the host Cougars (4-5, 3-3 Big 12) rallied in fourth quarter to upset the Wildcats (7-2, 4-2).

Trailing 19-10 to start the fourth quarter, Chriss threw a 1-yard touchdown to Maliq Carr with 11 minutes left. After forcing a punt, Chriss rushed for a 41-yard touchdown with 2:31 to go.

Chriss, who finished 11 of 11, also rushed for 75 yards.

NO. 20 SMU 48, NO. 18 PITTSBURGH 25: Brashard Smith ran for 161 yards with a 71-yard sprint for the first his two rushing touchdowns and made a nifty tiptoe catch for another score as the host Mustangs (8-1, 5-0) overwhelmed the previously undefeated Panthers (7-1, 3-1) to remain tied for the conference lead in their ACC debut.