Reynaldo Lopez was facing baseball’s hottest team with a defense behind him that wasn’t at the top of its game Wednesday night at Guaranteed Rate Field.

So holding the Indians to one earned run over six innings was a big success for the rookie right-hander in his fourth White Sox start.

Lopez gave up six hits with two walks and two strikeouts, but the Sox couldn’t solve Indians right-hander Carlos Carrasco in a 5-1 loss. Carrasco pitched a three-hitter on just 97 pitches to help the Indians extend their winning streak to 14 games. He struck out nine and gave up the only run on Adam Engel’s solo homer with two out in the ninth.

Lopez pitched around a couple of jams partially created by defensive miscues.

He loaded the bases in the fourth on a walk and a pair of singles on which left fielder Nicky Delmonico and second baseman Alen Hanson couldn’t make plays. But Lopez held the Indians to only a run on Tyler Naquin’s sacrifice fly to left field. It was Lopez’s third quality start since he was called up Aug. 11.

Carlos Santana hit a two-run homer off reliever Danny Farquhar in the eighth, and the Indians added a run on Matt Davidson’s second error of the game.

Meanwhile, Carrasco opened the game with four perfect innings and held the Sox to just two baserunners over the first eight.

Lineup in flux: Before the game, the Sox reinstated Delmonico from the disabled list, where he had been since Aug. 25 with a sprained right wrist. The Sox brought Yoan Moncada off the DL on Tuesday, but manager Rick Renteria stuck to a plan to rest him Wednesday as he returns to playing without the benefit of a rehab assignment.

“We have to ease everybody back in,” Renteria said.

Shortstop Tim Anderson was scratched about an hour before the game because he wasn’t feeling well, Sox officials said.

Storm worries: Renteria said he knows many of his players’ minds and hearts will be with their families as Hurricane Irma potentially could affect their homes in Puerto Rico, the Dominican Republic, Cuba and Florida. Renteria said much of his wife’s family is in Puerto Rico.

“It keeps everything in perspective, all of the things that are going on, the things that just happened in Houston,” Renteria said. “We’re all cognizant of the realities of life and the things that are really important. There are going to be a lot of people keeping track.”

On the farm: The Class A Kannapolis South Atlantic League playoff opener Wednesday was postponed because of rain. Pitching prospect Dylan Cease was scratched from his start in that game because of shoulder fatigue, but the Sox expect Cease to pitch in instructional league this fall.