When Broncos run

Denver has found a formula for success through the run game. During the Broncos’ two-game win streak, they have rushed for 298 yards. The Bills have held opponents to under 100 yards rushing for three straight games. Edge: Broncos

When Broncos pass

Wilson has been an effective deep-ball thrower this season. He has a 121.4 passer rating when attempting passes for 20-plus yards, according to Pro Football Focus. Buffalo’s secondary has battled injuries. Cornerback Tre’Davious White suffered a season-ending torn Achilles, while safety Micah Hyde (neck/stinger) and cornerback Christian Benford (hamstring) did not practice on Thursday and Friday. Edge: Bills

When Bills run

Bills running back James Cook has rushed for a team-best 506 yards on 108 attempts. He is one yard away from tying his total from last season. Denver’s defense held the Chiefs to 62 rushing yards in Week 8, suggesting it has plugged the holes that made the Broncos the worst rush defense in the league. Edge: Even

When Bills pass

Josh Allen is fourth in passing yards (2,423) and first in quarterback rating (75.3) but has thrown the most interceptions in the league with nine. He has thrown an interception in five straight games, and the Bills are 3-4 when he throws at least one pick. The Broncos, on the other hand, have recorded six picks since Week 4. Expect cornerback Pat Surtain II to spend a ton of time shadowing Bills wideout Stefon Diggs. Edge: Bills

Special teams

The Broncos are first in punt and kick return average. Rookie Marvin Mims Jr. had a 31-yard punt return in the home win over the Chiefs. The Bills are one of five teams in the league that has allowed a punt return for a touchdown. Edge: Broncos

Coaching

Head coach Sean Payton has the Broncos on a two-game win streak and has finally been able to establish the physical run game he talked about since the offseason. Defensive coordinator Vance Joseph went from fans demanding him to be fired to having the defense shut down the Chiefs. Led by head coach Sean McDermott, the Bills started the season 3-1 and averaged 34.7 points per game. Since then, Buffalo is 2-3 and has lost two of its last three. Still, the Bills are a top-five offense in the league and have held opponents to under 20 points per game this season. Edge: Bills