A man shot and killed a stranger in the driveway of her rural Pennsylvania home on Thursday morning and then ambushed and shot two state troopers who responded to the call, leading to a standoff that ended with the police killing the suspect, authorities said.

The two injured troopers, Joseph Perechinsky and William Jenkins, who have been on the force for several years, were airlifted to a hospital and were in stable condition Thursday afternoon after surgery, the Pennsylvania State Police said.

The episode began when the suspect, whose name was not immediately released, shot and killed a neighbor in the driveway of her home shortly before 11:30 a.m. Thursday, the state police said. He then opened fire on Perechinsky and Jenkins when they responded to a report about an injured person at the home, which is along State Route 171 in Susquehanna County, police said.

The suspect later barricaded himself in a barn on his property nearby, brandishing the rifle he had used to shoot the troopers and the woman who was killed, said Trooper 1st Class Robert M. Urban, a state police spokesperson. The suspect failed to comply with police orders to stand down, Urban said, and officers shot him in the barn about three hours after the two troopers were shot.

Urban did not name the woman who was killed, but said she had never interacted with the man who shot her. That’s not unusual in the rural county, where neighboring homes are often separated by acres of land, Urban said. The episode took place around Thompson Township, which has fewer than 500 residents. It is less than 20 miles from the New York border and nearly 50 miles north of Scranton, Pa.