Lamar Jackson threw for 281 yards and five touchdowns, helping the visiting Baltimore Ravens overcome an early double-digit deficit and extend their winning streak to five games with a 41-31 victory Monday night over the Tampa Bay Buccaneers, who lost their top two receivers to injuries.

The two-time NFL MVP improved to 23-1 against NFC teams, the best mark by a quarterback against an opposing conference in NFL history. He’s 3-0 against the Bucs (4-3), who faded after taking a 10-0 lead with help from the 100th TD reception of Mike Evans’ career.

Evans departed with a hamstring injury after Baker Mayfield tried to connect with him in the end zone again, and late in the fourth quarter with the game out of reach, leading Bucs receiver Chris Godwin was carted off the field with a left ankle injury. ESPN declined to show replays of Godwin’s injury, which appeared to be severe.

Jackson completed 17 of 22 passes without an interception, including TD throws of 9 and 4 yards to Mark Andrews. He also tossed scoring passes of 49 yards to Rashod Bateman, 18 yards to Justice Hill and 11 yards to Derrick Henry, who rushed for 169 yards on 15 carries. Bateman had four catches for 121 yards.

The Ravens (5-2) rebounded from a slow start on defense, with cornerback Marlon Humphrey turning the game around with a pair of second-quarter interceptions — one of them in the Baltimore end zone. Jackson led a four-play, 80-yard TD drive after the first pick, and the second interception set up Justin Tucker’s 28-yard field goal for a 17-10 halftime lead.

Mayfield finished 31 of 45 passing for 370 yards, three TDs and two interceptions. Evans joined Hall of Famers Jerry Rice, Randy Moss, Marvin Harrison and Terrell Owens as the only players to have at least 100 TD receptions in the first 11 seasons of a career when he caught a 25-yard scoring pass in the first quarter.

Evans, who missed two days of practice last week with what the Bucs described as a nagging hamstring issue, appeared to aggravate the injury on the scoring reception. Mayfield nearly connected with him in the end zone again in the second quarter, but this time the ball glanced off Evans’ hands as he and Ravens cornerback Brandon Stephens went to the ground.

Evans was on the turf for several minutes before being helped up, limping to the locker room.

49ERS’ AIYUK TO HAVE MAJOR KNEE SURGERY: San Francisco 49ers star receiver Brandon Aiyuk will miss the rest of the season after tearing ligaments in his right knee.

Coach Kyle Shanahan said tests Monday confirmed the initial diagnosis that Aiyuk tore his ACL and would need major reconstructive surgery after getting hit on the knee while making a catch in the red zone late in the second quarter of a 28-18 loss to the Kansas City Chiefs on Sunday. Shanahan said Aiyuk also tore his MCL.

Aiyuk got hurt late in the first half when was hit on the knee after making a catch in the red zone. He stayed down for a few minutes before being carted to the locker room and was quickly ruled out for the rest of the game.

Aiyuk, who signed a $120 million, four-year extension in late August following a lengthy contract “hold in,” has 25 catches for 374 yards but no TDs this season. He was a second-team All-Pro last season when he had 1,342 yards receiving.

BROWNS QB WATSON TO HAVE SEASON-ENDING SURGERY: Deshaun Watson won’t finish the season as Cleveland’s starting quarterback for the second straight year.

He’s injured again, and the Browns have new problems.

Watson ruptured his right Achilles tendon in the first half of Sunday’s 21-14 loss to Cincinnati, collapsing as he began to run and leading some Browns fans to cheer while the divisive QB laid on the ground writhing in pain.

The team feared Watson’s year was over and an MRI on Monday confirmed the rupture. The Browns said Watson will have surgery this week and miss the rest of the season but “a full recovery is expected.”

Watson’s injury is a blow to the Browns (1-6), who have lost five straight in a season that began with massive expectations after the team made the playoffs last year.

RAIDERS QB O’CONNELL OUT 4 TO 6 WEEKS: Las Vegas Raiders quarterback Aidan O’Connell is expected to be out four to six weeks with a broken thumb, a person close to the situation said Monday.

The person spoke to The Associated Press on condition of anonymity because the Raiders have not made an announcement.

The person also said the injury to O’Connell, expected to be placed on injured reserve, wasn’t as bad as originally feared because of the location of the break in his throwing hand. O’Connell will go for a second opinion, the person said.

O’Connell was hurt in the first quarter of Sunday’s 20-15 loss to the Rams.