U.S. stocks tumbled Friday as the “Trump bump” that Wall Street got from last week’s presidential election, along with a cut to interest rates by the Federal Reserve, kept fading.

The S&P 500 dropped 1.3% for its worst day since before Election Day to close out a losing week. The Dow Jones Industrial Average fell 305 points, or 0.7%, and the Nasdaq composite sank 2.2%.

Makers of vaccines helped drag the market down after President-elect Donald Trump said he wants Robert F. Kennedy Jr., a prominent anti-vaccine activist, to lead the Department of Health and Human Services. Moderna tumbled 7.3%, and Pfizer fell 4.7% amid concerns about a possible hit to profits.

The 10-year Treasury’s yield held at 4.44%, where it was late Thursday, after swinging up and down. The two-year yield, which more closely tracks expectations for Fed action, fell to 4.31% from 4.36% late Thursday.

All told, the S&P 500 fell 78.55 points to 5,870.62. The Dow dropped 305.87 to 43,444.99, and the Nasdaq sank 427.53 to 18,680.12.

In stock markets abroad, London’s FTSE 100 fell 0.1% after data from the Office for National Statistics showed economic growth slowed to 0.1% in the July-September quarter from the 0.5% in the previous quarter. It was weaker than expected.

Tokyo’s Nikkei 225 gained 0.3% after data showed growth for Japan’s economy accelerated in the latest quarter, even as the Bank of Japan raised interest rates in July.

— Associated Press