ROME — Italian Premier Giorgia Meloni visited Pope Francis for 20 minutes in the hospital Wednesday and reported he was “alert and responsive” and full of good humor, despite his diagnosis of pneumonia and a complicated bronchial infection that has sidelined the 88-year-old pontiff for six days.

The Vatican said Francis’ overall condition remained stationary, but that blood tests showed a “slight improvement” in key inflammation indices. Francis also worked in the afternoon with his collaborators, the Vatican said in a late statement.

Meloni said she wanted to bring get-well wishes to the pope on behalf of the government and entire nation. “We joked around as always. He has not lost his proverbial sense of humor,” she said in a statement issued by her office.

Meloni is the first confirmed outside visitor known to have called on the pope, beyond his secretaries and medical team, since his admission Friday at Rome’s Gemelli hospital, where popes have their own suite on the 10th floor. Her visit, announced only after it was over, appeared aimed at sending a reassuring message, especially to Italians who haven’t seen even a photograph of Francis since Friday.

The Vatican has said Francis was up, eating and had gotten out of bed after a tranquil night, a day after tests confirmed he had pneumonia in both lungs on top of asthmatic bronchitis.

The Italian premier, who came to power in 2022 with a message touting her Christian credentials, has referred in glowing terms to the influence on her of Popes John Paul II and Benedict XVI, both reference points for European conservatives like herself. While she and Francis don’t see eye-to-eye on her crackdown on migrants, they have teamed up constructively on a campaign to reverse Italy’s low birthrate.

Her visit came as prayers were pouring in for Francis’ recovery. On Wednesday, Francis’ vicar for Rome urged all the faithful to devote an hour of silent prayer for the pope before evening vespers services, some visitors to Gemelli lit a candle in his honor and pilgrims who had planned to attend his weekly general audience came to St. Peter’s Square anyway to offer a prayer after it was cancelled.

“I think many people are disappointed but I think more importantly we really have to pray for his health,” said Sister Charlene, a nun from Singapore who was in the piazza.

Francis also received another get-well wish from U.S. Vice President JD Vance, whom the pope recently targeted in criticizing the Trump administration’ s plans for mass deportations of migrants.

“Let’s all say a prayer for Pope Francis, who appears to have some serious health issues,” Vance, a Catholic, posted on X from his private account.

Francis was admitted to the Gemelli hospital Friday after a weeklong bout of bronchitis worsened. On Monday, medical personnel determined that he was suffering from a polymicrobial respiratory tract infection, meaning a mix of viruses, bacteria and possibly other organisms had colonized in his respiratory tract. Late Tuesday, the Vatican said a chest CT scan showed the onset of bilateral pneumonia on top of asthmatic bronchitis, which is being treated with cortisone and antibiotics.

“I think the key will be how well and quickly he responds to treatment,” said Dr. Andrew Chadwick, a respiratory and intensive care specialist at Oxford University Hospitals.

Bronchitis can lead to pneumonia, which is a deeper and far more serious infection of the lungs’ air sacs.