PHILADELPHIA — Just one night after the Lakers had a 12-minute stretch when it felt like everything was going their way, they had an even more prolonged stretch on Tuesday when it felt like everything was unraveling.

The Lakers’ winning streak not only ended with a 118-104 blowout loss to the short-handed Philadelphia 76ers, but star big man Anthony Davis left the game in the first quarter with an abdominal injury.

Similar to Monday’s road win against the Charlotte Hornets, the Lakers got off to a good start against the 76ers (18-27), grabbing an 18-9 lead midway through the first.

The start was as good as it got for the Lakers, who fell to 26-19 with their first loss since falling to the Clippers on Jan. 19 at Intuit Dome.

The defeat was the Lakers’ first of their six-game “Grammy” trip, which continues with a matchup against the Washington Wizards on Thursday before Saturday’s game against the New York Knicks.

“Three (games) in four nights, back-to-back (games), I’m not sure where our collective brains were at,” coach JJ Redick said. “I understand the physical fatigue. We were a step slow all night on (Tyrese) Maxey, particularly in that (second) quarter.

“Frankly, you’re not going to win a game if somebody takes 19 more shots than you and gets eight more offensive rebounds. We’re throwing the ball everywhere. That is just, again, fatigue, mental and physical, just bad decision-making. Poor execution, very unorganized throughout the game.”

LeBron James led the Lakers with 31 points on 10-of-16 shooting to go with nine assists and eight rebounds, but the 21-time All-Star also had eight of the Lakers’ 22 turnovers that led to 27 points for the 76ers.

“We weren’t as mentally sharp as we should’ve been,” James said. “We made too many mistakes. That simple.”

Rookie Dalton Knecht scored 24 points off of the bench while Austin Reaves finished with 13 points, eight assists and six rebounds.

After appearing to hold the left side of his body after the game’s first timeout earlier in the quarter, Davis subbed out at the 2:10 mark of the first as part of the normal rotation and immediately went to the locker room for examination.

Davis, likely to be named a Western Conference reserve for the All-Star Game on Thursday, sat out for the rest of the night.

The Lakers said during the second quarter that Davis was questionable to return because of a strained abdominal muscle before ruling him out at halftime. There was no immediate timeline for Davis’ return to action. How and when he sustained the injury was unclear.

“When our best player goes out, it’s always challenging,” James said. “Especially in the game. If he’s out from the beginning, then we have a gameplan set. We know what to expect, we know what our lineup is gonna be. But when A.D. or any one of our guys go down throughout the course of a game, it’s just tough.

“But the level of concern? I think he’ll be fine.”

Davis finished with four points and two rebounds in 10 minutes, one night after recording 42 points and 23 rebounds against the Hornets for the fifth 40-point, 20-rebound game of his career.

After the score was tied at 25 at the end of the first quarter, the 76ers outscored the Lakers 48-32 in the second to take a 73-57 lead into halftime.

“Regardless of who’s playing, we gotta find a way to be better,” Reaves said. “Obviously it sucks when one of your best players is not available, but got to find a way to be better.”

The Lakers started the third quarter with Dorian Finney-Smith in Davis’ spot along with the starters.

The Lakers didn’t reduce their deficit below 12 points in the second half, with the 76ers — who were without Joel Embiid, Paul George, Andre Drummond, Caleb Martin, KJ Martin and Jared McCain — winning their third consecutive game.

Redick took James and the rest of the team’s rotation players out with the Lakers trailing 110-93 midway through the fourth.

Tyrese Maxey had 43 points on 15-of-26 shooting (4 for 11 from 3-point range) to pace Philadelphia. Kelly Oubre Jr. added 20 points, eight rebounds and five assists while Guerschon Yabusele and Eric Gordon each scored 14 points.

The Lakers also were without Jarred Vanderbilt, the team holding him out on the second night of a back-to-back after he missed the first 42 games of the season following surgery on his feet. Guard Gabe Vincent missed his second consecutive game with knee soreness.

PLAY TIME FOR BRONNY

With Vincent out, second-round draft pick Bronny James, the son of LeBron James, was in the Lakers’ first-quarter rotation for the first time.

Bronny missed all five of his shot attempts and turned the ball over three times while also recording three rebounds and an assist in a career-high 15 minutes.

“Just him giving us energy was the goal,” Redick said. “Maybe put him in a tough spot. Flying up (on Monday), (a) nationally televised game in Philly and all that stuff. He didn’t play well, but he’s been playing great in the stay-ready games and he’s been playing great in the G (League). So I have confidence in him but obviously didn’t provide that at a high level.”

Bronny has averaged 16.3 points, 4.2 assists and 4.3 rebounds in 10 G League games with the South Bay Lakers.

“I’d say just keeping my aggression up,” he said of what he’s looking to translate with the Lakers from his time in the G League. “Just trying to be aggressive every game and come out and play the right way. I know I do. Just coming here and bringing all the energy I can and playing the right way.”