KYIV, Ukraine>> Foreign Minister Dmytro Kuleba, one of Ukraine’s most recognizable faces on the international stage, resigned Wednesday ahead of an expected reshuffling of government leaders. Russian strikes, meanwhile, killed seven people in a western city, a day after one of the deadliest missile attacks since the war began.

Kuleba, 43, gave no reason for stepping down. Four other Cabinet ministers tendered their resignations late Tuesday, likely making this reshuffle the biggest since Russia’s invasion in February 2022.

Ukrainian President Volodymyr Zelenskyy indicated last week that the reshuffling was imminent, with the war poised to enter a critical stage and to mark its 1,000th day in November.

He said Wednesday that Ukraine needs “new energy, and that includes in diplomacy.” He said during a Kyiv news conference with visiting Irish Prime Minister Simon Harris that he could not announce any replacements yet because he did not know whether the candidates would accept his invitation to join the government.

Zelenskyy needs to keep up Ukraine’s morale amid the grinding war of attrition with its bigger neighbor and to steel the country’s resolve for what will be another hard winter. Russia has been smashing Ukraine’s power grid, knocking out some 70% of generation capacity and rupturing heat and water supplies.

Wednesday’s deadly attack on Lviv — a city near the border with NATO member Poland and far from the front lines — underscored how all of Ukraine is at the mercy of Moscow’s long-range capabilities.

Elsewhere, the nighttime strike wounded 52 people as well as killing seven, Ukraine’s rescue service said. The strike was carried out with a Kinzhal missile and drones and targeted defense industry enterprises, Russian news agency Tass said, citing the Russian Defense Ministry.

Local officials disputed the targeting claim. Lviv Mayor Andrii Sadovyi and the Ukrainian Catholic University published a photo of a family whose mother and three daughters were killed in the attack that struck their home. The father survived but was in critical condition, Sadovyi said

During the war, Kuleba has been second only to Zelenskyy in carrying Ukraine’s message and needs to an international audience, whether through social media posts or meetings with foreign dignitaries. Several Ukrainian media outlets, citing unnamed sources, said Kuleba’s deputy, Andrii Sybiha, would become the country’s chief diplomat.

The new foreign minister will likely accompany Zelenskyy next week to the U.N. General Assembly in New York, which is an opportunity to lobby global leaders for their support.