The Angels didn’t score in the first inning, but they did score first, and the Red Sox are 11-24 when opponents do that.

Make that 11-25.

The Red Sox overcame an early three-run deficit, but wasted countless scoring opportunities. They pitched their way to extra innings, only to lose 4-3. They’re an MLB-worst 6-17 in one run games.

Brayan Bello held the Angels off until the third, which is more than his fellow starters have been able to say of their most recent outings. His scoreless first inning snapped a four-game streak of Sox pitchers allowing at least one run in the opening frame.

The Red Sox entered Tuesday with 43 runs allowed in first innings, tied for third-worst mark in the majors and one shy of the American League-leading Athletics. The Red Sox have allowed opponents to score in the first inning an AL-leading 24 times this season, second only to the Colorado Rockies, who’ve only won 10 of their 60 games.

Bello outlasted his Anaheim counterpart, Yusei Kikuchi, by a full frame. The Red Sox righty pitched six innings and allowed three earned runs on seven hits, walked two, struck out four, and hit one batter. He threw a season-high 103 pitches (65 for strikes).

The Angels scored all three of their regulation runs in the third inning. Bello plunked the leadoff man, Jo Adell, and walked Chris Taylor. Zach Neto’s single, coupled with a throwing error from Ceddanne Rafaela, got Anaheim on the board, and Nolan Schanuel’s two-run single increased the lead to three.

Kikuchi yielded three earned runs on eight hits and struck out five in his five innings. He also issued five walks.

The Red Sox, too, got on the board in the third, but unlike the Angels, they didn’t do as much as they could have. Connor Wong led off with a single and Campbell and Jarren Duran followed with back-to-back doubles, the latter an RBI knock. Campbell and Duran then stood in scoring position watching Rob Refsnyder walk to load the bases after Rafael Devers struck out, only for Romy Gonzalez and Abraham Toro to strike out and ground out to leave them there.

It looked like the Red Sox would continue wasting opportunities all night when Rafaela finally changed the game with a personal-best blast in the sixth. The game-tying two-run homer, which soared 426 feet to the back of the seats atop the Green Monster at 112.1 mph, was the hardest-hit ball of his career, and six feet further than his previous record for home-run distance.

It was a rough night on defense for several of Boston’s newer players. The first Boston error came on a throw by Rafaela in the third, as Zach Neto’s single plated the Angels’ first run. Then, hours after Cora said the Red Sox wouldn’t rule out anything when it came to helping a struggling Kristian Campbell improve, even an option to Triple-A, the rookie received a chorus of boos when he stumbled trying to glove a grounder by Nolan Schanuel in the fifth. Instead of a potential double play for the first two outs, the Angels had men on first and second with no outs, and Campbell had a fielding error.

As the bullpens battled it out in the later innings, both teams wasted opportunities. The Angels went 2 for 6 with runners in scoring position and left seven men on base in their nine innings, and the Red Sox entered the bottom of the ninth 1 for 8 RISP with eight left.

The boos were far louder when Kenley Jansen took the mound in the bottom of the ninth with the game knotted at three. Coming off an effortless-looking save in Monday night’s 7-6 Angels victory, Jansen found himself in immediate trouble the second time around. He issued a leadoff walk to Campbell, and after pinch-runner David Hamilton stole second, intentionally walked Devers.

And of course, the Red Sox let their former closer off the hook.

Bello and the bullpen shut the Angels out for the last six innings of regulation, but they quickly retook the lead in extras. The 10th inning began with yet another Red Sox error. Zack Kelly couldn’t grab Schanuel’s trickling leadoff sacrifice bunt, which allowed the Angels to put runners on the corners. He then walked Mike Trout to load the bases. A run came home to score on Taylor Ward’s double play before Jorge Soler popped out to end the inning.

Reid Detmers wasn’t as generous. He struck out pinch-hitter Carlos Narváez, got Trevor Story swinging, and Rafaela popped up to cement yet another one-run loss.

The Red Sox are 29-34.