Sedrick Alexander ran for two touchdowns, Randon Fontenette scored on a pick-six and Diego Pavia outplayed Heisman Trophy candidate Jalen Milroe as host Vanderbilt stunned Alabama 40-35 on Saturday for the Commodores’ first win over the nation’s top-ranked team.

Vanderbilt (3-2, 1-1 Southeastern Conference) had lost all 60 games against AP top-five teams, according to SportRadar. The Commodores hadn’t beaten Alabama on the field in 40 years, but they snapped a 23-game skid making big play after big play to give coach Clark Lea his alma mater’s biggest win ever.

The Commodores scored the first 13 points and took a 16-point lead that was their largest ever over the No. 1 team in the country. Only Jam Miller running for his second TD just before halftime trimmed that to 23-14.

Pavia was 16 of 20 for 252 yards and two TDs for Vanderbilt. Milroe was 18 of 24 for 310 yards, a TD and an interception for Alabama (4-1, 1-1 SEC).

no. 3 ohio state 35, iowa 7 >> Emeka Egbuka caught three touchdown passes and Jeremiah Smith made another one-handed grab for a score as the host Buckeyes sputtered early before burying the Hawkeyes (3-2, 1-1 Big Ten)

Quarterback Will Howard was 21 for 25 for 209 yards passing and four touchdowns and ran for 28 yards and a score as Ohio State (5-0, 2-0 Big Ten) cleaned up its first-half mistakes and put up 21 consecutive points in the third quarter.

NO. 5 GEORGIA 31, AUBURN 13 >> Trevor Etienne ran for two touchdowns as the host Bulldogs bounced back from their first regular-season loss in almost four years with a workmanlike victory over the struggling Tigers (2-4, 0-3 SEC).

Georgia (4-1, 2-1 SEC) made it eight straight wins in the Deep South’s oldest rivalry.

NO. 25 TEXAS A&M 41, NO. 9 MISSOURI 10 >> Le’Veon Moss ran for a career-high 138 yards with three touchdowns and the host Aggies handed the Tigers (4-1, 1-1 SEC) their first loss. It’s the fifth straight win for Texas A&M (5-1, 3-0 SEC).