SANTA CLARA >> The 49ers aren’t quite ready to give Christian McCaffrey the green light to play in Monday’s season opener, after he was limited in practice by calf and Achilles issues.

McCaffrey is listed as questionable on the injury report while the only 49ers ruled out are defensive end Yetur Gross-Matos and linebacker Dee Winters.

Left guard Aaron Banks (pinky) is also questionable, while safety Talanoa Hufanga (knee) is doubtful to make his return from last November’s anterior cruciate ligament tear, though he’s made an impressive entry into practices the past two weeks.

Coach Kyle Shanahan declined to elaborate whether McCaffrey will be a game-time decision. Kickoff is set for 5:15 p.m. Monday at Levi’s Stadium against the New York Jets.

McCaffrey strained a calf in the 49ers’ penultimate game last regular season, to which Shanahan said: “I don’t know if they’re related but they’re similar”

As for Hufanga, Shanahan said; “I don’t think it’s necessarily too soon (to play). He’s looked great. We’re trying to be safe and smart with him. We haven’t ruled him out in case there is an emergency situation.”

Wide receiver Jauan Jennings (ankle) and running back Isaac Guerendo (groin) are off the injury report.

Injuries from the preseason finale will delay the debuts of Gross-Matos (knee) and Winters (ankle). Gross-Matos established himself as the No. 3 defensive end upon his signing from the Carolina Panthers, and the 49ers will look for second-year end Robert Beal Jr. to serve as their top backup behind Nick Bosa and Leonard Floyd.

Winters, a sixth-round pick last year, flashed throughout the offseason and camp, but it appears that De’Vondre Campbell will start alongside Fred Warner at linebacker in the base defense.

Super Bowl hangover? >> Only two teams have ever lost a Super Bowl one season and then won it the next. The Dallas Cowboys lost Super Bowl V 16-13 to the Baltimore Colts on Jan. 17, 1971, then came back to beat the Miami Dolphins in Super Bowl VI a year later 24-3.

The New England Patriots lost Super Bowl LII 41-33 to the Philadelphia Eagles to wrap up the 2017 season, then beat the Los Angeles Rams 13-3 the following year.

That’s the entire list, but it doesn’t carry much significance to tight end George Kittle.

“I’m assuming the stat exists because when you play long into the season, if you’re a team that doesn’t handle it right you might be beat up and sore and discouraged,” Kittle said. “I haven’t felt that by any means. I think our team has a ton of energy and is ready to roll.

“There’s a lot of things I don’t think about until you guys ask me questions and I try not to think about them again.”

upgrades >> Bosa noted that he and Kevin Givens are the defensive line’s only holdovers dating back to the 2019 season.

“I really like the new guys and think we’ve improved,” Bosa said. “Leonard brings something to our defense that we haven’t had – a guy who can make plays all over the field and has just a motor where he doesn’t get tired. Having a guy like that who is super long and athletic and can rush and this game is going to bring the best out of him. I’m excited.”