FORT WORTH, Texas >> Deion Sanders had Colorado ready for prime time Saturday after all of the hype and attention in the nine months since he was hired.

Shedeur Sanders, the coach’s son, threw for 510 yards with four touchdowns, the game-winner a 46-yard catch-and-run by freshman Dylan Edwards with 4:25 left, and the Buffaloes pulled off an opening shocker with a 45-42 win over 17th-ranked TCU, last year’s national runner-up.

Edwards caught three touchdowns, including a 75-yarder in the opening minute of the second half when he turned another short pass into a big play. He also ran for another score.

Two-way starter Travis Hunter, the former top recruit who came with the quarterback and coach from FCS school Jackson State, had 11 catches for 119 yards. As a defensive back, he had one of the two interceptions that TCU’s Chandler Morris threw in or near the end zone.

Hunter, Edwards and Shedeur Sanders are among 87 newcomers at Colorado, which won only one game last season and has only two winning records since 2005.

Colorado outgained TCU 565-541.

NO. 1 GEORGIA 48, TENNESSEE-MARTIN 7 >> Carson Beck overcame a sluggish first half to throw a 54-yard touchdown pass to Mekhi Mews and Georgia, the two-time defending national champion, leaned on its defense to overwhelm Tennessee-Martin.

Georgia showed it must make progress on offense if it can realize its dream of becoming the first team to win three straight national championships in The Associated Press poll era.

NO. 2 MICHIGAN 30, EAST CAROLINA 3 >> J.J. McCarthy threw three touchdown passes to Roman Wilson, helping Michigan rout East Carolina.

NO. 3 OHIO ST 23, INDIANA 3 >> Miyan Williams rushed for two touchdowns and new quarterback Kyle McCord picked up his first victory since being named the starter for Ohio State in a win over Indiana.

NO. 6 SOUTHERN CALIFORNIA 66, NEVADA 14 >> Caleb Williams threw for 319 yards and hit Tahj Washington with two of his five touchdown passes, leading Southern California past Nevada.

NO. 10 WASHINGTON 56, BOISE ST 19 >> Michael Penix Jr. threw for 450 yards and matched his career high with five touchdown passes and Washington overwhelmed Boise State.

NO. 11 TEXAS 37, RICE 10 >> Quinn Ewers passed for three touchdowns and ran for another as Texas overcame a sluggish start with an overwhelming third quarter to beat Rice.

NO. 12 TENNESSEE 49, VIRGINIA 13 >> Joe Milton III threw two touchdown passes and ran for two other scores as Tennessee routed Virginia.

NO. 13 NOTRE DAME 56, TENNESSEE ST 3 >> Sam Hartman passed for 194 yards and two touchdowns and Notre Dame’s defense didn’t allow a touchdown for a second straight game as the Irish beat Tennessee State.

NO. 15 OREGON 81, PORTLAND ST 7 >> Bo Nix threw for 287 yards and three touchdowns before heading for the bench early in the third quarter and Oregon built a 43-point halftime lead en route to a victory over Portland State.

NO. 16 KANSAS STATE 45, SOUTHEAST MISSOURI STATE 0 >> Will Howard threw for 297 yards and two scores, added touchdowns running and receiving to complete a rare trifecta, and led Kansas State past Southeast Missouri State.

NO. 19 WISCONSIN 38, BUFFALO 17 >> Chez Mellusi ran for 157 yards and two touchdowns, Braelon Allen added 141 yards and two more scores and Wisconsin started the first season of Luke Fickell’s coaching tenure with a victory over Buffalo (0-1).

NO. 20 OKLAHOMA 73, ARKANSAS ST 0 >> Dillon Gabriel completed 19 of 22 passes for 308 yards and two touchdowns — all in the first half — and Oklahoma beat Arkansas State.

NO. 22 MISSISSIPPI 73, MERCER 7 >> Jaxson Dart threw four touchdown passes, including three to Tre Harris in the opening four minutes as Mississippi rolled to a rout of Mercer.

NO. 25 IOWA 24, UTAH STATE 14 >> Cade McNamara threw for 191 yards and two touchdowns in his Iowa debut to help the Hawkeyes beat Utah State.