MONday night football

Saints (2-2) at Chiefs (4-0)

When: 8:15 p.m. EDT Monday

TV: ESPN

BetMGM NFL odds: Chiefs by 5 1/2

Series record: Chiefs lead 7-5.

Last meeting: Chiefs beat Saints 32-29 on Dec. 20, 2020, in New Orleans.

Last week: Saints lost to Falcons 26-24; Chiefs beat Chargers 17-10.

Saints player to watch: QB Derek Carr is familiar with Kansas City from his days playing for the AFC West-rival Raiders. He has struggled the past two weeks, throwing for just 142 yards in a loss to Philadelphia and 239 in a loss in Atlanta. Carr also has been picked off in each of the past three games.

Chiefs player to watch: TE Travis Kelce finally had a big game last week against the Chargers, catching seven passes for 89 yards. He still has not scored this season, but the sudden uptick in production for the four-time All-Pro was important after the Chiefs lost WR Rashee Rice to a knee injury.

Key matchup: Saints RB Alvin Kamara against the Kansas City run defense, which has shut down some of the league’s best through the first four weeks. The Ravens’ Derrick Henry managed 46 yards in the opener, the Bengals’ Zack Moss just 34 the next week, Falcons star Bijan Robinson had 16 carries for 31 yards, and JK Dobbins was held to 32 yards for the Chargers last week. Kamara has had at least 15 carries and 77 yards rushing in every game this season.

Series notes: The Saints and Chiefs have only played 12 times since their first meeting at Tulane Stadium on Sept. 25, 1972. The Chiefs have won the past three, including a 32-29 victory on Dec. 20, 2020. The Saints have not won in Kansas City since a 30-20 victory on Nov. 16, 2008.

Stats and stuff: The Saints lost to the Falcons last week despite not allowing an offensive TD. ... Kamara scored his 84th career TD last week, tying Hall of Fame WR Calvin Johnson, Andre Rison and Herschel Walker for 59th on the career list. ... Chiefs QB Patrick Mahomes made his 100th start last week against the Chargers. He has an NFL-record 78 wins during that stretch.

— Associated Press

colts (2-2) at Jaguars (0-4)

When: 1 p.m. EDT Sunday

TV: CBS

BetMGM NFL odds: Jaguars by 3

Series record: Colts lead 27-19.

Last meeting: Jaguars won 37-20 on Oct. 15, 2023, in Jacksonville.

Last week: Jaguars lost at Texans 24-20; Colts beat Steelers 27-24.

Key matchup: Travis Etienne and Tank Bigsby versus an Indy defense that ranks 31st in the league against the run, allowing 164.8 yards a game on the ground. Etienne and Bigsby have been bright spots for the Jaguars, leading the way on a unit that ranks second in the NFL by averaging 5.74 yards per rushing attempt.

Series notes: Jacksonville swept the series last season, giving the Jags wins in 10 of the past 16 meetings. ... The Jaguars have won the past nine home games against Indy, including one that was played in London. ... A season-ending loss at the Jags in 2021 prevented the Colts from making the playoffs.

Stats & stuff: Indianapolis has consecutive wins. ... The Colts are tied for third in the NFL with 20 rushes of 10 or more yards and are tied for fourth with 17 total plays of 20 or more yards. ... The Jaguars will induct former coach Tom Coughlin into the franchise’s ring of honor at halftime. Coughlin will join OT Tony Boselli, WR Jimmy Smith, RB Fred Taylor and QB Mark Brunell alongside original team owners Wayne and Delores Weaver in the “Pride of the Jaguars.”

BILLS (3-1) AT TEXANS (3-1)

When: 1 p.m. Sunday

TV: CBS

BetMGM NFL odds: Texans by 1

Series record: Texans lead 6-5.

Last meeting: Bills beat Texans 40-0 on Oct. 3, 2021, in Buffalo.

Last week: Bills lost to Ravens 35-10; Texans beat Jaguars 24-20.

Key matchup: Houston WR Stefon Diggs will face his former team for the first time since a blockbuster trade brought him to the Texans. The four-time Pro Bowler is second on the team with 25 receptions for 233 yards. He has two receiving touchdowns and had the first rushing score of his career against the Jaguars. He spent the past four seasons in Buffalo where he had more than 1,100 yards receiving each year, highlighted by an NFL-leading and career-high 1,535 yards in 2020.

Series notes: The Bills won the most recent game in the series but Houston took the previous two games, including an overtime victory in a wild-card playoff game in the 2019 season. … These teams first met in Houston’s inaugural season in 2002 when Buffalo got a 31-24 win. … Houston’s first win in the series came in a 12-10 victory in 2003.

Stats & stuff: The Bills’ loss to Baltimore ended an NFL-record streak of 43 straight games in which Buffalo had not lost by more than six points. The run began a week following a 41-15 loss to Indianapolis on Nov. 21, 2021.

RAiders (2-2) at Broncos (2-2)

When: 4:05 p.m. Sunday

TV: Fox

BetMGM NFL odds: Broncos by 2 1/2

Series record: Raiders lead 73–54–2.

Last meeting: Raiders beat Broncos 27-14 on Jan. 7, 2024, in Las Vegas.

Last week: Raiders beat Browns 20-16, Broncos beat Jets 10-9.

Key matchup: Raiders run defense vs. Broncos RB Javonte Williams. The Raiders rank 24th in the league, allowing 137.5 yards a game on the ground. Williams struggled through the first three weeks of the season before coming up big on a soggy day in East Rutherford, New Jersey, last week when he ran for 77 yards on 16 carries against the Jets. That pushed him over 2,000 rushing yards and quieted the critics who were wondering why Sean Payton was sticking with him when he averaged less than 2.2 yards per carry in Weeks 1-3 and managed just 52 yards on 24 runs.

Series notes: Denver has lost eight consecutive times to the Raiders, their longest skid since losing 16 in a row in the series between 1963 and 1971. The Broncos’ most recent win over the Raiders came on Dec. 29, 2019, the last game for the Oakland Raiders before the franchise moved to Las Vegas.

Stats & stuff: Raiders QB Gardner Minshew’s only career start against the Broncos was in 2019 with Jacksonville when he threw for 213 yards and two TDs without an interception in the Jaguars’ 26-24 win in Denver. ... Las Vegas defenders Adam Butler and Christian Wilkins each have 12 QB pressures, both players ranking in the top 10 among DTs. Butler’s 10.5% is his highest since at least 2018, according to NFL Next Gen Stats. Wilkins is at 9.2%, the second highest of his career.

cardinals (1-3) at 49ers (2-2)

When: 4:05 p.m. Sunday

TV: Fox

BetMGM NFL odds: 49ers by 7 1/2

Series record: 49ers lead 36-29.

Last meeting: 49ers beat Patriots 45-29 in Glendale, Ariz., on Dec. 17, 2023.

Last week: Cardinals lost to Commanders 42-14; 49ers beat Patriots 30-13.

Key matchup: Cardinals pass D vs. 49ers QB Brock Purdy. The Arizona native has picked apart the Cardinals in three career starts. Purdy has completed 51 of 66 passes for 703 yards, eight TDs, no INTs and a 150.4 passer rating in those three wins. The Cardinals have allowed a 110.4 passer rating this season, third worst in the NFL.

Series notes: The 49ers have won four straight in the series by an average of 22 ppg. ... The season series has ended in a sweep in eight of the past nine seasons with Arizona winning both games five times and San Francisco three times. They split in 2020. ... The Cardinals have a 6-4 record at Levi’s Stadium since it opened in 2014.

Stats & stuff: Cardinals second-year WR Michael Wilson had one of his best games as a rookie in San Francisco last season. He had 76 yards receiving and two TDs. ... RB James Conner has scored 17 TDs against NFC West opponents since joining the Cardinals in 2021. ... Purdy leads the NFL with 14 completions of at least 25 yards. ... Purdy has run for eight first downs this season. ... Purdy has a 55.8 passer rating when targeting Brandon Aiyuk this season after posting a 124.6 rating last season when throwing to Aiyuk. ... Fred Warner had his 10th career INT last week, joining Keena Turner as the only players in Niners history with at least 10 career INTs and 10 sacks.

Packers (2-2) at Rams (1-3)

When: 4:25 p.m. Sunday

TV: CBS

BetMGM NFL odds: Packers by 3

Series record: Packers lead 50-47-2.

Last meeting: Packers beat Rams 20-3 at Green Bay on Nov 5, 2023.

Last week: Packers lost to Minnesota 31-29; Rams lost to Chicago 24-18.

Key matchup: Packers RB Josh Jacobs vs. Rams defensive front. Jacobs has been solid in his first four games away from the Raiders, averaging 4.6 yards per carry. Where Green Bay needs the bruiser to step up is in the red zone, where the offense is operating at 46.7% efficiency in scoring touchdowns, and Jacobs getting his first score in a Packers jersey might help unlock a turnaround. The Rams are struggling at stopping the run, giving up 4.98 yards per carry. The defensive line is getting pushed around, though linebackers Troy Reeder and Christian Rozeboom have done a decent job of minimizing the damage after contact. If they can’t stabilize and unleash a talented pass rush, it is going to be a long season in Los Angeles.

Series notes: The Packers have won four straight over the Rams, including an NFC divisional playoff game in the 2020 season which marked QB Jared Goff’s last appearance for Los Angeles before he was dealt to Detroit as part of the blockbuster trade for Matthew Stafford. … Stafford was not available in last season’s loss to the Packers because of a thumb injury. Brett Rypien started in his absence and was 13 of 28 passing for 130 yards and one interception. … Green Bay has won nine of the past 10 games against Los Angeles.

giants (1-3) at Seahawks (3-1)

When: 4:25 p.m. Sunday

TV: CBS

BetMGM NFL odds: Seahawks by 6

Series record: Seahawks lead 11-10

Last meeting: Seahawks beat Giants 24-3 on Oct. 2, 2023.

Key matchup: Seahawks passing offense vs. Giants passing defense: The Seahawks have the top passing offense in the NFL through four weeks, thanks in part to Geno Smith’s career-high 395 yard passing day last week in Detroit. Smith has thrown for 300 yards twice this season, and threw for 289 against Miami in Week 3. Meanwhile, the Giants passing defense ranks 14th in the NFL with an average of 193 yards allowed per game through the air, and have yet to allow a 300-yard passer this season.

Series notes: The Seahawks have won six of the past seven matchups between these two teams, going back to 2011 … The only Giants win in that time against Seattle came on Dec. 6, 2020, when the Giants beat the Seahawks in Seattle 17-12. … The Giants and Seahawks first played each other on Nov. 28, 1976, Seattle’s inaugural year. The Giants won that game 28-16 in New York. … This is the third consecutive season the Giants and Seahawks have played each other. Seattle won each of the first two matchups.

Stats & stuff: QB Daniel Jones has completed 70% of his passes the past two games, and he has thrown two TD passes in each of his two road games this season. ... RB Devin Singletary has run for a touchdown in five of his past six road games. ... The Giants were limited to 26 yards rushing by Dallas. ... The Seahawks need five more wins to reach 400 regular-season wins in franchise history. … WR DK Metcalf needs 100 receiving yards to have four consecutive 100-yard games, extending his franchise record.