Natasha Lyonne is laying her (credit) cards on the table, along with her Nicorette and Tea Tree Therapy mint toothpicks. We’re sitting in the back house of the Studio City office she shares with producing partner Maya Rudolph, and this emptying of pockets came as a response to talk of her moving, part time at least, to L.A.

Lyonne holds up her driver’s license, emphasizing it was issued by the state of New York, and when I study the photo for a beat too long, she points at the picture and says, “Just because I look like s— right now doesn’t mean that’s not what I look like, Glenn. Do I come out on tour with you and say, ‘Hey, Mr. Danzig, how come you don’t always look like you do when you’re on stage?’ Do you hear this, Root Beer?”

Root Beer, Lyonne’s longtime Maltipoo BFF, barks, sounding a note of disapproval. Lyonne and I met about 20 minutes ago and from the moment we laid eyes on each other, she’s been calling me Glenn Danzig, though there’s precious little overlap between the heavy metal icon and myself. But Lyonne likes to free-associate. Thoughts tumble forth, heavy on references to ‘70s movies, Elliott Gould, Bob Fosse, John Cassavetes and possibly becoming a cyborg one day. That she quit smoking for the first time in her life a few weeks ago isn’t necessarily helping her focus, she notes.

“It’s confusing, you know what I mean?” Lyonne says, comparing giving up nicotine to kicking heroin many years ago. “It seems like the stakes are much lower and yet arguably for your health, they might be even higher now.

“I should become an addiction specialist,” she continues. “I think I am. Like when you’re a junkie, you’re kicking dope all the time, so it’s an ongoing nightmare. Like, I strongly don’t recommend heroin. There’s one takeaway you can get from this conversation. And quitting cigarettes is weird as hell. But it seemed like a good window to try. On set, I behave like a young Bob Fosse. And when I say ‘young,’ I mean ‘middle-aged.’ I mean ‘almost dead’ Bob Fosse.” She pauses. “Listen, I could start up again at any time. But I’m not getting any younger, and I’d like to still be making ‘Poker Face’ when I’m old and just sort of shuffling around, you know? So why not try?”

Who doesn’t want to see Lyonne making “Poker Face” well into her golden years? Every generation needs its version of Peter Falk’s Lt. Columbo, and Lyonne staked an early claim to that title with the first season of her terrific mystery-thriller series, which debuted earlier this year on Peacock. Lyonne plays Charlie Cale, a woman possessing a superpower — she always knows when people are lying. Circumstances force her to move from town to town where she uses her intuition to solve crimes. Each self-contained episode delivers a new homicide (you really don’t want Charlie showing up where you live), along with a different set of guest stars — the likes of Nick Nolte, Chloë Sevigny, Hong Chau and Joseph Gordon-Levitt among them.

Rian Johnson, no stranger to mysteries with his “Knives Out” movies, created “Poker Face” as a showcase for Lyonne. The two met through Johnson’s wife, film historian Karina Longworth. Lyonne loves Longworth’s “You Must Remember This” podcast and, years ago, wanted to adapt the episode focused on Lena Horne and Paul Robeson and the Hollywood blacklist into a project. It never got off the ground, but the friendship endured, leading to her connection with Johnson. He had been toying with the idea of a case-of-the-week TV show, and in Lyonne, he believed he had an actor that audiences would love to hang with on a weekly basis.

“You need to find somebody who genuinely has that spark of charisma on screen and that’s a rare coin,” Johnson says by phone, mentioning Falk and James Garner in “The Rockford Files.” “When I saw Natasha in [the Netflix series] ‘Russian Doll,’ it clicked for me. That effortless charisma just comes across on the screen.

“I think the way two people click creatively has as much to do with how they’re different as how they’re the same,” Johnson continues. “And our temperaments fall into a peanut butter and chocolate situation. She’s not the person you see on screen, but her brain operates at a much higher frequency than mine.”

Is it a frequency that only Root Beer can hear? Possibly. Johnson says he could only watch and marvel when Lyonne directed and starred in the standout “Poker Face” episode “The Orpheus Syndrome,” a macabre slice of horror that doubled as a love letter to Oscar-winning VFX artist Phil Tippett and also featured Lyonne running around in a horse costume. Sometimes when actors direct themselves, they’ll lament the multitasking and perhaps scale back their screen time. Lyonne, Johnson says, embraced the overload because “her brain needs that.”

“She’s into puzzles and word games and she’ll do, like, eight of them at once,” Johnson says. “She has an endless capacity to keep multiple plates spinning. Not even capacity. It’s a need. I heard David Mamet say this, that writers write for the same reason beavers cut wood — to stop their teeth from aching. That’s Natasha and life.”

When I ask Lyonne what she’s currently working on — and remember, this is what she calls her down time — she says she’s writing a few TV shows, writing some movies with friends, reworking a movie script she finished some time ago and writing a book. And in the past half-hour, she suggested that we team up with Root Beer to invent a better herbal cigarette because “those honeysuckle things are just the worst.”

Lyonne also just turned 44, and explains that she’s dealing with a midlife crisis by embracing a few new hobbies. She has taken up surfing, for one. Pressed for other pastimes, Lyonne removes her black baseball cap, runs her hands through her red haystack of hair and laughs.