ORCHARD PARK, N.Y. >> The Buffalo Bills stand to open the season minus two new free-agent defensive line additions upon learning Larry Ogunjobi and Michael Hoecht both face six-game suspensions for violating the NFL’s performance-enhancing drugs policy, general manager Brandon Beane announced Friday.

“It’s not ideal to have two guys with that, but both guys have never had any issues off the field,” Beane said. “It’s a tough lesson of where do you get your supplements or whatever happened.”

Whatever happened is suddenly hampering the Bills retooled line, with Ogunjobi and Hoecht both expected to be unavailable to play until Week 7. Under NFL rules, the two players would not be barred from the team facility for the first four weeks, before being allowed to begin practicing.

Beane said the team was aware of Hoecht’s positive test before agreeing to sign the hybrid defensive lineman/linebacker to a three-year, $24 million contract Monday.

Hoecht took responsibility in revealing he tested positive for testosterone, which he said was supplied to him by his long-time trainer.

“I’m ultimately mad at nobody but myself. I got complacent. I trusted someone I shouldn’t have trusted,” said Hoecht, who spent his first four seasons with the Los Angeles Rams. “It was a mistake. It was careless. And it’s ultimately my responsibility.”

As for Ogunjobi, who signed a one-year contract with $8 million guaranteed, Beane said the player revealed he had just received notice of testing positive upon arriving in Buffalo on Thursday to sign a contract the two sides agreed to on Tuesday. The 30-year-old has no history of testing positive and, last season, was the Pittsburgh Steelers nominee for Walter Payton Man of the Year award.

“It was a situation where I don’t really know what it was. But I think it was a tainted supplement that I took,” Ogunjobi said. “But I understand the league, we have an obligation to understand what we put in our body, and I take full responsibility for that.”

Beane credited Ogunjobi for being upfront even before the player’s B sample has been tested, while adding it’s not ideal to have two players facing season-opening suspensions.

Beane said the Bills would have passed on targeting the eighth-year player in free agency had they known of the positive test.