LONDON — Lorenzo Musetti threw his head back and spread his arms wide to celebrate reaching his first Grand Slam semifinal at Wimbledon, then covered his face with both hands.

His 3-6, 7-6 (5), 6-2, 3-6, 6-1 victory over Taylor Fritz on Wednesday was a big deal, to be sure. After all, the 25th-seeded Musetti, a 22-year-old from Italy, never had made it past the third round at the All England Club — or past the fourth round at any major tournament — until this fortnight.

Now, though, comes a far tougher test: taking on Novak Djokovic.

“He probably knows, better than me, the surface and the stadium, for sure,” Musetti said with a chuckle, aware he’ll be making his Centre Court debut on Friday. “Jokes apart, he’s a legend everywhere, but especially here in Wimbledon.”

This will be Djokovic’s record-tying 13th semifinal at Wimbledon alone — equaling Roger Federer — and 49th Slam semifinal overall, extending a mark he already held. As Musetti pursues his first major title, Djokovic seeks a 25th, including what would be an eighth at the All England Club.

Djokovic’s smooth trip through this year’s bracket was made even easier when the man he was supposed to play in the quarterfinals Wednesday, Alex de Minaur, pulled out with a hip injury hours before their match was scheduled to begin.

Musetti was forced to work for his spot in the final four: His 3 1/2-hour victory over the 13th-seeded Fritz was the 37th five-setter at the All England Club this year, the most at any Grand Slam tournament.

Musetti acknowledged he didn’t get off to an ideal start but added, “I played my best tennis at the end. I kept the best for the end.”

Playing at a sun-swathed No. 1 Court against Fritz, an American who is one of the sport’s biggest servers but fell to 0-4 in major quarterfinals, Musetti managed to accumulate 13 break points and convert six. The outcome-determining break came on a forehand winner by Musetti that made it 2-0 in the last set; moments later, another break made it 4-0.

Musetti’s first break came early in the second set and that, he said, altered the course of the evening.

“Immediately, I changed my mind. I changed my attitude,” he said. “And that probably made the difference.”

With Queen Camilla, the wife of King Charles III, in the stands and joining fans in doing the wave, there was not a ton of variety exhibited by either player; they were mainly content to trade groundstrokes from the baseline. But Musetti did manage to accrue points with effective drop shots, occasionally following them with successful passing attempts or lobs.

Djokovic had knee surgery less than a month before the start of play at the All England Club. But despite limitations on his movement, the 37-year-old Serb has dropped only two sets so far — facing a qualifier in the first round, a wild-card entrant in the second and only one seeded player, No. 15 Holger Rune.

Instead of going up against No. 9 de Minaur on Wednesday, Djokovic will get three full days off before meeting Musetti. The other semifinal Friday is defending champion Carlos Alcaraz against Daniil Medvedev.

Djokovic and Musetti have played each other six times previously. Djokovic has won five of those, including a five-setter at this year’s French Open that concluded after 3 a.m. It was in Djokovic’s following match in Paris that he tore the meniscus in his right knee.

“We know each other pretty well. They’ve always been a huge fight so I expect a big, big fight. It’s going to be one of the toughest challenges,” Musetti said, “but I am an ambitious guy and I like to be challenged.”

In the women’s quarterfinals Wednesday, 2022 champion Elena Rybakina grabbed nine of the last 11 games to defeat No. 21 Elina Svitolina 6-3, 6-2, and No. 31 Barbora Krejcikova eliminated No. 13 Jelena Ostapenko 6-4, 7-6 (4) in a matchup between two past champions at the French Open.

The other women’s semifinal on Thursday is No. 7 Jasmine Paolini of Italy against unseeded Donna Vekic of Croatia.