TEHRAN, Iran >> Iran’s top diplomat insisted Wednesday that Tehran will never stop enriching uranium, reinforcing the Islamic Republic’s hard line ahead of a new round of indirect talks with the United States over its fast-advancing nuclear program.

Iran’s foreign ministry later confirmed it has agreed to take part in the next round of talks Friday in Rome.

The comments by Iranian Foreign Minister Abbas Araghchi come after multiple rounds of talks between the two nations, including at an expert level over the details of a possible deal. American officials including President Donald Trump, Mideast envoy Steve Witkoff and Secretary of State Marco Rubio maintain that Iran must give up enrichment — something it didn’t do in its 2015 nuclear deal with world powers.

“I have said it before, and I repeat it again: uranium enrichment in Iran will continue — with or without an agreement,” Araghchi said, according to state television.

Araghchi added that Iran was “currently reviewing whether to participate in the next round and when to take part” in talks with the U.S. Negotiators previously met in Muscat, Oman, and Rome but Trump’s trip to the Mideast last week delayed any new meeting.

Later Wednesday, Oman’s foreign minister announced that the fifth round of indirect talks will be Friday in Rome. The minister made the comment on social media. Oman has long served as a mediator, facilitating quiet diplomacy amid tensions over Iran’s nuclear program and regional security.

Iran’s foreign ministry spokesman, Esmail Baghaei, in a post on X later confirmed that Tehran has agreed to take part in the new round of talks. Washington has not confirmed the meeting or announced whether it will attend.

“We have never abandoned diplomacy. We will always be present at the negotiating table, and the main reason for our presence is to defend the rights of the Iranian people,” Araghchi said. “We stand against excessive demands and rhetoric at the table.”

Iran’s supreme leader, Ayatollah Ali Khamenei, said a day earlier he didn’t expect the negotiations to produce a deal.