CHARLESTON, S.C. >> The U.S. death toll from Hurricane Ian has risen to more than 40 as Florida authorities on Friday afternoon confirmed several drowning deaths and other fatalities.

According to CNN, at least 42 deaths have been reported in the state. Homes on the coast were washed out to sea, buildings were smashed throughout the state, and floodwater ruined homes and businesses and trapped residents, even inland in places like the Orlando area.

After losing steam as it inundated Florida, a revived Hurricane Ian battered coastal South Carolina on Friday, ripping apart piers and filling neighborhoods with calf-high water, after the deadly storm caused catastrophic damage in Florida and trapped thousands in their homes.

Ian’s center came ashore near Georgetown with much weaker winds than when it crossed Florida’s Gulf Coast on Wednesday as one of the strongest storms to ever hit the U.S. As it moved across South Carolina, Ian dropped from a hurricane to a post-tropical cyclone.

Sheets of rain whipped trees and power lines and left many areas on Charleston’s downtown peninsula under water. Four piers along the coast, including two at Myrtle Beach, collapsed into the churning waves and washed away. Online cameras showed seawater filling neighborhoods in Garden City to calf level.Ian left a broad swath of destruction in Florida, flooding areas on both of its coasts, tearing homes from their slabs, demolishing beachfront businesses and leaving more than 2 million people without power.

At least 42 deaths that are suspected to be related to Ian have been reported in Florida, according to CNN. That includes 16 in Lee County, 12 in Charlotte County, eight in Collier County, three in Volusia County, one in Polk County and two in unincorporated Sarasota County, according to officials.

Rescue crews piloted boats and waded through riverine streets Thursday to save thousands of people trapped amid flooded homes and shattered buildings.

Florida Gov. Ron DeSantis said Friday that crews had gone door-to-door to over 3,000 homes in the hardest-hit areas.

“There’s really been a Herculean effort,” he said during a news conference in Tallahassee.

Among those killed were an 80-year-old woman and a 94-year-old man who relied on oxygen machines that stopped working amid power outages, as well as a 67-year-old man who was waiting to be rescued and fell into rising water inside his home, authorities said.

Officials fear the death toll could rise substantially, given the wide territory swamped by the storm.

Florida Division of Emergency Management Director Kevin Guthrie said responders have focused so far on “hasty” searches, aimed at emergency rescues and initial assessments, which will be followed by two additional waves of searches. Initial responders who come across possible remains are leaving them without confirming, he said Friday, describing as an example the case of a submerged home.

“The water was up over the rooftop, right, but we had a Coast Guard rescue swimmer swim down into it and he could identify that it appeared to be human remains. We do not know exactly how many,” Guthrie said.

Desperate to locate and rescue their loved ones, social media users shared phone numbers, addresses and photos of their family members and friends online for anyone who can check on them.

Orlando residents returned to flooded homes Friday, rolling up their pants to wade through muddy, knee-high water in their streets. Friends of Ramon Rodriguez dropped off ice, bottled water and hot coffee at the entrance to his subdivision, where 10 of the 50 homes were flooded and the road looked like a lake. He had no power or food at his house, and his car was trapped by the water.

“There’s water everywhere,” Rodriguez said. “The situation here is pretty bad.”

Municipal rescuers, private teams and the Coast Guard used boats and helicopters Friday to evacuate residents who stayed for the storm and then were cut off from the mainland when a causeway collapsed. Volunteers who went to the island on personal watercraft helped escort an elderly couple to an area where Coast Guard rescuers took them aboard a helicopter.

Ian made landfall in South Carolina with maximum sustained winds of 85 mph. When it hit Florida’s Gulf Coast on Wednesday, it was a powerful Category 4 hurricane with 150 mph.

In North Carolina, heavy rain bands and winds crept into the state Friday afternoon. Gov. Roy Cooper warned residents to be vigilant, given that up to 8 inches of rain could fall in some areas, with high winds.

“Hurricane Ian is at our door. Expect drenching rain and sustained heavy winds over most of our state,” Cooper said. “Our message today is simple: Be smart and be safe.”

In Washington, President Joe Biden said he was directing “every possible action be taken to save lives and get help to survivors.”