Two people were arrested after police officers witnessed a shooting in West Pullman on the Far South Side that wounded a 22-year-old man Thursday morning, police said.

A third suspect remained at large, and Alsip School District 126 canceled classes for the day as a precaution as police searched the area.

Two high schools in the area went into shelter-in-place mode, officials said. Students and teachers at Shepard High School in Palos Heights and Eisenhower High School in Blue Island stayed behind locked doors during first period, according to Bob McParland, spokesman for Community High School District 218. Police later told school officials it was safe to resume normal schedules.

The incident began around 2:40 a.m. when officers on an unrelated call heard shots from at least two different kinds of guns near the 11800 block of South Lowe Avenue, police said.

They responded on foot and saw someone in a vehicle firing shots at a group of people, police said in a statement. They identified themselves as police when people in the car began to fire at them. One of the officers drew his weapon and returned fire but did not hit anyone, police said. The officers were also not hit.

The vehicle carrying the shooters drove west on 119th Street. The officers radioed a description and police spotted it as the car crashed more than four miles away, in the 4400 block of West 119th Street in Alsip.

Three people ran from the car and two of them were arrested, police said. The third was at large. A weapon was recovered from the car, police said.

Back at the scene of the shooting, a 22-year-old man was found with a gunshot wound to the leg, police said. He was taken to Advocate Christ Medical Center, and his condition was stabilized.

The man was one of 14 people shot across Chicago between Wednesday morning and early Thursday.

A 39-year-old man was shot and killed about 7:25 p.m. in Back of the Yards, police said. He was hit in the torso in the 4300 block of South Paulina Street and was pronounced dead at the University of Illinois Hospital. Earlier, Fire Department officials said the victim was taken to Stroger.

At 7 p.m., a 24-year-old man was shot and killed in Bronzeville. He was in the 4700 block of South Prairie Avenue when someone shot him in the leg and shoulder. He went to Northwestern Memorial Hospital. Police said his condition initially was stabilized, but he later was pronounced dead at 7:49 p.m.

He was identified as Christopher Walters, of the 6200 block of South Champlain Avenue, according to the Cook County medical examiner's office.

Information was not immediately available about the circumstances of the shooting.

Other shootings included:

At 3 a.m., a 22-year-old man was shot in the 1900 block of South Damen Avenue in the Heart of Chicago neighborhood. He went to Stroger Hospital with a gunshot wound to the back. Details of the shooting were not available.

About 1:55 a.m., two men ages 26 and 44 were shot and critically wounded in South Austin. They were in a car in the 800 block of North Leamington Avenue when they heard gunfire. The older man was shot twice in the arm and once in the back. The younger man was shot in the back and leg. Both were taken to Mount Sinai Hospital in critical condition.

About 10:35 p.m. Wednesday, a 24-year-old man was shot in Little Village. He was taken to Mount Sinai Hospital with a gunshot wound to the ankle after an attack in the 2200 block of South Ridgeway Avenue. He would not tell investigators any details about the incident, according to police.