When: 2 p.m. Saturday

Where: Arizona Stadium

TV: KDVR-31

Radio: 850 AM, 94.1 FM

BetMGM Line: CU +3, O/U 58.5

Weather: Partly sunny, 71 degrees at kickoff.

Series history: CU leads 16-10

Three storylines

WR depth test: Four Colorado wide receivers left last week’s 31-28 loss to Kansas State with injuries. Buffs coach Deion Sanders says two-way star Travis Hunter “should play, for certain,” and Jimmy Horn Jr. is also expected to play. But Omarion Miller is out for the season after having surgery, and Terrell Timmons will sit out Saturday. All that means more opportunities for transfers LaJohntay Wester (26 catches, 318 yards, 7 TDs) and Will Sheppard (22catches, 330 yards, 2 TDs) — both of whom have been productive when given the chance.

Shutting down Shilo?: “I’ve been seeing everybody turn on me,” sixth-year safety Shilo Sanders said on Tuesday after he struggled against Kansas State and DJ Giddens in “the worst game of my life.” Coach Prime said his middle son played “horrible.” It’s possible the younger Sanders, returning from surgery after being injured against Nebraska, was just rusty. Or maybe he wasn’t ready to get back on the field. If he misses multiple tackles against Arizona like he did against K-State, Deion could have a difficult choice to make. The coach is big on accountability. He even benched Shilo in the SWAC championship game for being late to a meeting at Jackson State. And with a combined 13 tackles against CSU, Baylor and UCF, Carter Stoutmire looked good in Shilo’s absence.

Midseason vibe check: At 4-2, the Buffs have the same record they did at this point last season — but the vibes are much different. A 42-6 drubbing at Oregon and an agonizingly close 48-41 loss to USC at home felt like the beginning of the end after a 3-0 start. CU went on to beat Arizona State 27-24 on the road before crashing out with a six-game losing streak and falling short of bowl eligibility. This season, the highs haven’t been quite so high and the lows, at least so far, haven’t been all that low. This evened-out CU program mirrors the relatively flat Big 12 hierarchy this year, where any team could conceivably beat any other team.

Predictions

Sarah Kelly, deputy sports editor: CU 31, Arizona 24

Colorado has the better quarterback and boasts the Big 12’s best red-zone defense (No. 7 nationally). Wildcats receiver Tetairoa McMillan is a nightmare, and his stats reflect that: He leads the Big 12 with 742 receiving yards. And Arizona’s defense will be welcoming back leading tackler Jacob Manu, who was controversially ejected in the first quarter last week at BYU. Both teams can get a little sloppy, but ultimately the K-State loss galvanizes the Buffs going into Tucson.

Sean Keeler, sports columnist: CU 31, Arizona 28

If you constructed a roster to nullify the Buffs, basically, it would look like Kansas State’s. Big, physical, killer pass rush, pound the ball, chew clock, don’t turn it over, grind away a game — and keep Shedeur Sanders cooling his jets on the sidelines. Utah’s that sort of team. Arizona ain’t. These ‘Cats give the ball away an average of twice per contest, boast the nation’s No. 84 rushing attack (140.83 yards per game) and are tied for 80th in sacks per tilt (1.83). Tetairoa McMillan is a bad matchup, but he’s a bad matchup for half the corners running around the NFL, too. Arizona also ranks 110th nationally in turnover margin. And in a game of inches, that’ll kill you. Right, Vic Fangio?

Matt Schubert, sports editor: CU 45, Arizona 31

A conference schedule that once looked daunting for CU now has a much more manageable feel. The league’s four most disappointing teams — Oklahoma State, Utah, Kansas and, yes, Arizona — are all on the Buffs’ dance card over the next seven weeks. If a run to the conference title game is going to happen, the Buffs need to knock off every single one of them. Here’s guessing an Arizona secondary that had trouble keeping New Mexico off the scoreboard can’t hold up against CU’s array of weapons. Time for Shedeur Sanders and Co. to rack up some stats.