BEERSHEBA, Israel >> President Donald Trump said Thursday he will decide within two weeks whether the U.S. military will get directly involved in the conflict between Israel and Iran given the “substantial chance” for renewed negotiations over Tehran’s nuclear program, as the two sides attacked one another for a seventh day.

Trump has been weighing whether to attack Iran by striking its well-defended Fordo uranium enrichment facility, buried under a mountain and widely considered to be out of reach of all but America’s “bunker-buster” bombs. His statement was read out by White House press secretary Karoline Leavitt.

Earlier in the day, Israel’s defense minister threatened Iranian Supreme Leader Ayatollah Ali Khamenei after Iranian missiles crashed into a major hospital in southern Israel and hit residential buildings near Tel Aviv, wounding at least 240 people. Israel’s military “has been instructed and knows that in order to achieve all of its goals, this man absolutely should not continue to exist,” Defense Minister Israel Katz said.

As rescuers wheeled patients out of the smoldering hospital, Israeli warplanes launched their latest attack on Iran’s nuclear program.

Prime Minister Benjamin Netanyahu said he trusted that Trump would “do what’s best for America.” Speaking from the rubble and shattered glass around the Soroka Medical Center in Beersheba, he added: “I can tell you that they’re already helping a lot.”

A new diplomatic initiative seemed to be underway as Iran’s Foreign Minister Abbas Araghchi prepared to travel Friday to Geneva for meetings with the European Union’s top diplomat and counterparts from the United Kingdom, France and Germany.

The open conflict between Israel and Iran erupted last Friday with a surprise wave of Israeli airstrikes targeting nuclear and military sites, top generals and nuclear scientists. At least 657 people, including 263 civilians, have been killed in Iran and more than 2,000 wounded, according to a Washington-based Iranian human rights group.

Iran has retaliated by firing 450 missiles and 1,000 drones at Israel, according to Israeli army estimates. Most have been shot down by Israel’s multitiered air defenses, but at least 24 people in Israel have been killed and hundreds wounded.

Israel’s Home Front Command asserted that one Iranian ballistic missile fired Thursday morning had been rigged with fragmenting cluster munitions. Rather than a conventional warhead, a cluster munition warhead carries dozens of submunitions that can explode on impact, showering small bomblets around a large area and posing major safety risks on the ground. The Israeli military did not say where that missile had been fired.

At least 80 patients and medical workers were wounded in the strike on Soroka Medical Center. The vast majority were lightly wounded, as much of the hospital building had been evacuated in recent days.

Iranian officials insisted they had not sought to strike the hospital and claimed the attack hit a facility belonging to the Israeli military’s elite technological unit, C4i. The website for the Gav-Yam Negev advanced technologies park, some 2 miles from the hospital, said C4i had a branch campus in the area.

The Israeli army did not respond to a request for comment. An Israeli military official, speaking on condition of anonymity in line with regulations, acknowledged that there was no specific intelligence that Iran had planned to target the hospital.

Many hospitals in Israel, including Soroka, had activated emergency plans in the past week. They converted parking garages to wards and transferred vulnerable patients underground. Israel also has a fortified, subterranean blood bank that kicked into action after Hamas’ Oct. 7, 2023, attack ignited the ongoing war in the Gaza Strip.

Doctors at Soroka said the Iranian missile struck almost immediately after air raid sirens went off, causing an explosion that could be heard from a safe room. The strike inflicted the greatest damage on an old surgery building and affected key infrastructure, including gas, water and air-conditioning systems, the medical center said.

The hospital, which provides services to around 1 million residents, had been caring for 700 patients at the time. After the strike, the hospital closed to all patients except for life-threatening cases.

Iran has long maintained its nuclear program is for peaceful purposes. But it is the only non-nuclear-weapon state to enrich uranium up to 60%, a short, technical step away from weapons-grade levels of 90%.

Israel is widely believed to be the only country with a nuclear weapons program in the Middle East but has never acknowledged the existence of its arsenal.

The Israeli air campaign has targeted Iran’s enrichment site at Natanz, centrifuge workshops around Tehran, a nuclear site in Isfahan and what the army assesses to be most of Iran’s ballistic missile launchers. The destruction of those launchers has contributed to the steady decline in Iranian attacks since the start of the conflict.

Israeli airstrikes reached into the city of Rasht on the Caspian Sea early Friday, Iranian media reported. The Israeli military had warned the public to flee the area around Rasht’s Industrial City, southwest of the city’s downtown. But with Iran’s internet shut off to the outside world, it’s unclear just how many people could see the message.