Jacksonville at Detroit

It would be difficult to overstate the nature of this mismatch. Detroit can do no wrong. Even with Jared Goff throwing five picks last week against a good Houston team, the Lions came back and won. They’re explosive offensively and defensively and have a real case as the best team in football. The Jags, meanwhile, are spiraling at 2-8 and will again be without quarterback Trevor Lawrence. The result? Detroit is a two-touchdown home favorite. You don’t see that kind of line in the NFL often.

Lions 35, Jaguars 17