Denver comic Adam Cayton-Holland’s acclaimed 2018 book, “Tragedy Plus Time: A Tragi-Comic Memoir,” has been adapted into a movie that will feature some recognizable Hollywood stars.

The announcement, first reported by Deadline, named actor and filmmaker Jay Duplass (“Search Party”) as director. He’s helming the production that’s already started shooting in Atlanta. Retitled “See You When I See You,” the dramedy is inspired by the book’s examination of the Cayton-Holland family, an eccentric but loving Denver clan that’s tested to its breaking point when Cayton-Holland’s younger sister, Lydia, dies by suicide.

The tragedy rocked the real-life Denver comedy scene and birthed Cayton-Holland’s one-man show “Happy Place,” which also examines raw grief through humor and pathos.

The “Tragedy Plus Time” memoir (named after the axiom “Tragedy plus time equals comedy”) was awarded the 2019 Colorado Book Award for Creative Non-Fiction.

The movie will star Cooper Raiff (“Cha Cha Real Smooth”), David Duchovny (“The X-Files,” “Californication”), Hope Davis (“Succession”), Kaitlyn Dever (“Booksmart”), Lucy Boynton (“Bohemian Rhapsody”), and Ariela Barer (“How to Blow Up a Pipeline”).

It’s “the kind of deeply personal dramatic comedy that I grew up on, that made me want to become a filmmaker in the first place,” Duplass said, according to Deadline.

The film is paid for by Astute Films and produced by Astute’s Fred Bernstein, Cayton-Holland, and Winter Coat Films’ Kumail Nanjiani and Emily V. Gordon (the Oscar-winning “The Big Sick”), as well as executive producers Rick Jackson, Mark Duplass, Jay Duplass and Mel Eslyn of Duplass Brothers Productions, Jeff David co-producing, Shuli Harel as co-executive producer, and CAA Media Finance repping sales, Deadline reported.

Cayton-Holland is well-known locally as one-third of the Grawlix comedy troupe, with Andrew Orvedahl and Ben Roy, and co-created and co-starred in the truTV series “Those Who Can’t,” the network’s first-ever scripted series.