NORRISTOWN, Pa. — The first accuser to testify at Bill Cosby’s retrial described the comedian Wednesday as ‘‘a serial rapist’’ as she parried with his lawyers, while a second accuser tearfully confronted the comedian over a 32-year-old assault allegation: ‘‘You remember, don’t you, Mr. Cosby?’’

And a third accuser, who was a 24-year-old bartender in 1982, said Cosby gave her two pills that made her lose consciousness. She testified Wednesday that she woke up naked in bed with the comedian, believing they’d had sex.

Janice Baker-Kinney said she believes Cosby gave her Quaaludes, a now-banned sedative. She said she still blames herself for getting knocked out, telling jurors, ‘‘I don’t want to have that guilt and shame.’’

The courtroom dramatics prompted mistrial requests from Cosby’s lawyers — which were denied — as prosecutors began putting on a parade of women who say Cosby drugged and molested them long before he met Andrea Constand, the chief accuser in his sexual assault retrial.

The first woman to testify, Chelan Lasha, told jurors Cosby gave her a little blue pill he described as an antihistamine to help her get over a cold, along with two shots of amaretto ‘‘to help break up the cough.’’

The combination immobilized her and rendered her unable to speak. Cosby then assaulted her, Lasha said.

associated press