LOWELL — Family members of Gloribel Orengo packed a courtroom here Tuesday, sobbing and muttering during the arraignment of a Worcester woman accused of taking part in the fatal attack on the mother of four.

Middlesex prosecutors said Amirilies Huertas-Perez, 23, had hit the 44-year-old Orengo twice in the head with a full bottle of Hennessy cognac during a fight Saturday night at a Lowell house party that spilled out into the parking lot near the residence.

Orengo’s 28-year-old son, who family members said has Down Syndrome, looked on during the brawl.

The victim may have been run over by a car as it ended, authorities said.

Huertas-Perez was charged with assault and battery with a dangerous weapon causing serious bodily injury. She was ordered held on $30,000 cash bail.

As Huertas-Perez was led away, Orengo’s family members could no longer contain their anger, raging at the suspect in English and Spanish despite the entreaties of a Lowell District Court officer.

Outside the courthouse, a person who identified herself as Orengo’s daughter crumpled to the ground.

“My best friend was killed,’’ said the woman, who did not give her name. “This is not OK. What am I going to do without my mom?’’

Her emotional response came as authorities continued to look for another suspect in the case: a man who was allegedly driving the stolen black Acura MDX that witnesses said hit Orengo as participants in the brawl drove away.

According to a police report, that suspect had escaped State Police after a 130-mile-per-hour chase that began on Interstate 495 in Boxborough hours after the altercation.

The car eventually crashed into a home, but police did not find the man.

Orengo’s family members said they were upset that Huertas-Perez was allowed bail. Assistant Middlesex District Attorney Megan McGovern said that more charges could follow.

Defense attorney James B. Krasnoo said in court that the bottle of Hennessy was not necessarily the crucial element in the attack, and noted that investigators are still working to confirm Orengo’s cause of death.

“We have no autopsy report yet, not surprisingly, to indicate the reason this person died,’’ the attorney said. “We don’t yet know whether that was a severe enough injury to cause this person to fall to the ground.

Orengo’s second-oldest son, Luis Barreto, said he wants the other people allegedly involved in the fight to face charges, too.

“I want justice,’’ he said, “I want all of them arrested.’’

According to the police report, the group had been thrown out of a party on Pawtucket Boulevard before the fight outside in a parking lot.

Orengo knew Huertas-Perez through family, her son said.

The hosts, who included a long-time friend of his mother’s, ordered Orengo and her son to leave, but also ordered Huertas-Perez out at the same time, putting both women in the parking lot at the same time, the son said.

However, Orengo was accompanied only by her son, Alejandro Barreto, while Huertas-Perez had several allies with her.

The group beat and kicked Orengo, authorities said, and Huertas-Perez later allegedly admitted to participating before they all took off.

Following the assault, relatives were told by a witness, Alejandro Barreto cradled his mother in his arms and shouted for help, drawing the attention of rescuers.

Orengo had been his caretaker since he was born.

Luis Barreto said his brother is devastated.

“He’s really hurt,’’ he said. “He’s taking the whole blame on himself.’’

Andy Rosen can be reached at andrew.rosen@globe.com. John R. Ellement can be reached at ellement@globe.com. Follow him on Twitter @JREbosglobe.