JERUSALEM — Israeli leaders criticized Palestinian President Mahmoud Abbas Monday for a fiery, invective-filled speech against President Trump, in which Abbas proclaimed the US role as arbiter of the Mideast conflict over, attacked the administration’s envoys, and described Israel as a colonial conspiracy.

Israeli Defense Minister Avigdor Lieberman said Abbas had ‘‘lost his senses’’ and had given up on the prospect of peace negotiations in favor of open confrontation with both Israel and the United States.

Israeli Education Minister Naftali Bennett, head of the pro-settler Jewish Home Party, said the speech represented Abbas’s swan song.

Prime Minister Benjamin Netanyahu, during a trip to India, said Abbas ‘‘tore off the mask’’ and exposed what he called the truth. ‘‘The root of the conflict between us and the Palestinians is their continuous refusal to recognize the Jewish state in any borders,’’ he said on Facebook.

In a rambling, 2½-hour speech Sunday night, the Palestinian leader sharply escalated his rhetoric, lashing out at the United States, Israel, Britain, and even other Arab leaders, whom he told to ‘‘go to hell’’ for criticizing him. He pronounced the peace process dead, and accused Israel of killing it.

The speech came at a time of great frustration for the 82-year-old Abbas, who after 13 years in power has made little progress in his goal of establishing an independent Palestinian state on lands captured by Israel in 1967.

The rival Hamas militant group now controls the Gaza Strip, his erstwhile Arab allies have quietly moved closer to Israel or turned their attention to other pressing matters such as Iran. Abbas has also lost faith in the United States as a Mideast broker after Trump’s recognition of Jerusalem as Israel’s capital last month, and he is deeply unpopular with his own people.

In the address, Abbas attacked Trump over the Jerusalem decision and rebuked Trump’s recent Twitter comment threatening to cut American aid and alleging the Palestinians were no longer willing to negotiate a peace deal.

Abbas called Trump’s moves a ‘‘slap in the face’’ and threatened that the Palestinians ‘‘will slap back,’’ without elaborating.