Toronto Blue Jays slugger Josh Donaldson strained his right calf and left Wednesday’s 5-3 loss at the Tampa Bay Rays, who salvaged a split in the four-game series.

The AL MVP was unable to run out a grounder, limped back to the dugout and was replaced at third base in the bottom of the inning by Darwin Barney, who moved over from second base.

Ryan Goins took over for Barney at second.

‘‘The calf just sort of locked up,’’ Donaldson said. ‘‘I tried to go three or four innings with it. It was just one of those situations where one, I didn’t think I was quite able to play defense the way I wanted to, and two, if I had to try and run, it was pretty difficult. But I don’t think it’s too serious and, hopefully, I’ll be back for our next game.’’

Donaldson hit a three-run homer in the third off Matt Moore. Troy Tulowitzki nearly made it 6-0 later in the inning, but his drive with two on was caught by center fielder Kevin Kiermaier near the wall at the deepest part of the ballpark.

Steven Souza Jr.’s first multihomer game helped the Rays to a second straight late come-from-behind victory. His second home run of the game was a go-ahead, three-run drive in the eighth.

‘‘Just to even it up with those guys over there was so big for us,’’ Souza said. ‘‘It’s a great team over there. Obviously a playoff team and one of the best in the American League.’’

Souza pulled Tampa Bay to 3-2 in the sixth with a solo homer off J.A. Happ. Tampa Bay has homered in a team-record 18 consecutive games dating to Sept. 20.

Evan Longoria and Desmond Jennings singled off Gavin Floyd (0-1) in the eighth, and Arnold Leon relieved with one out. Souza homered to center for his fourth hit of the game, tying his career high.

Tampa Bay won 3-2 Tuesday night on a disputed game-ending double play in the ninth that was the result of a video review under baseball’s new slide rules.

Logan Forsythe had given Tampa Bay the one-run lead with a two-run homer in the eighth of that game.

‘‘Not a real good 24 hours, put it that way,’’ Toronto manager John Gibbons said.

The Blue Jays failed in a bid to win their fourth series in the last 26 trips to Tropicana Field.

‘‘Obviously an exciting win,’’ Tampa Bay manager Kevin Cash said. ‘‘Anytime you drop the first two and you can come back, whether it’s the opening series, last series, whatever, it feels pretty good. It’s a quality split because we put ourselves in a little bit of a hole.’’

Moore gave up three runs, five hits and two walks in five innings with six strikeouts. Happ allowed two runs and seven hits in six-plus innings

Yankees 16, Astros 6 —Starlin Castro homered and drove in five runs, Mark Teixeira had four RBIs as New York trounced Houston to record its first victory of the season. Teixeira and Castro each hit a three-run homer.

Carlos Beltran also went deep as the Yankees erupted for 17 hits.

Dodgers 7, Padres 0 — Japanese pitcher Kenta Maeda homered in the second at-bat of his major league debut with Los Angeles and blanked San Diego, making the Padres, who were outscored 25-0 in its season-opening series against the visiting Dodgers, the first team in major league history to be shut out in its first three games.

Mariners 9, Rangers 5 — Robinson Cano homered twice and drove in five runs, including a two-run homer that capped Seattle’s five-run ninth to defeat Texas in the finale of a three-game opening series.

Rangers closer Shawn Tolleson (0-1) allowed all five batters he faced to reach base and score.

Pinch-hitter Nori Aoki and No. 9 batter Ketel Marte started the ninth with consecutive singles, and Leonys Martin had a tying RBI double. Kyle Seager then had a two-run single before Cano’s fourth homer chased Tolleson.

Cano has homered in all three games for Seattle and is the first Mariners player ever with four homers in the first three games of the season. He had 21 homers last season, and his fourth didn’t come until his 71st game on June 26.

Joaquin Benoit (1-0) pitched a scoreless eighth.

Brewers 4, Giants 3 —Chris Carter hit his first home run for Milwaukee, then had a tie-breaking sacrifice fly in the seventh inning as the Brewers spoiled the San Francisco debut of Jeff Samardzija, who allowed three runs and eight hits in 5? innings.

Carter’s third-inning home run was his fourth off Samardzija. He left Houston to sign with the Brewers after hitting 90 homers during three years with Houston.

Tigers 7, Marlins 3 — Jarrod Saltalamacchia homered and drove in four runs and Francisco Rodriguez struck out Giancarlo Stanton to end the game with the bases loaded as Detroit dealt Miami ace Jose Fernandez his first loss in 27 career starts at home.

Victor Martinez hit a two-run homer and Nick Castellanos had an RBI double in the sixth that chased Fernandez (0-1).

Orioles 4, Twins 2 — Chris Davis, the reigning major league home run champ, hit a solo homer to back an effective pitching performance by Yovani Gallardo in his Baltimore debut at chilly Camden Yards.

Davis also scored the winning run in the season opener and is off to a strong start after receiving a $161 million, seven-year contract in January.

Gallardo (1-0) allowed one run and two hits in five innings, striking out four and walking three. The right-hander signed a $22 million, two-year contract in February after pitching for Texas last season.

Zach Britton, the last of four Baltimore relievers, struck out the side in the ninth for his first save.

Pirates 5, Cardinals 1 ­— Juan Nicasio pitched six dominant innings in his Pittsburgh debut and Francisco Cervelli hit a two-run double to help sweep St. Louis in the opening three-game set.

Nationals 3, Braves 1 — Pinch-hitter Matt den Dekker, recalled from the minors earlier in the day, hit a tie-breaking, two-run double in a three-run seventh that led Washington. Stephen Strasburg (1-0) allowed one run and six hits in six innings.

Jonathan Papelbon gave up one-out singles to Adonis Garcia, who had three hits, and Nick Markakis in the ninth. With Garcia at third and pinch-runner Drew Stubbs on second with two outs, Papelbon struck out A.J. Pierzynski for his second save.

Bud Norris (0-1), making his Atlanta debut after signing as a free agent, gave up three runs and six hits in seven innings.

Red 3, Phillies 2 — Scott Schebler doubled with the bases loaded and one out in the ninth as Cincinnati took advantage of another meltdown by Philadelphia’s bullpen.

Philadelphia wasted a lead in the eighth inning of a 6-2 defeat on opening day. Ahead all the way until the ninth, the Phillies let another one get away.

Trying to hold a 2-1 lead, Dalier Hinojosa (0-1) gave up three singles that loaded the bases with one out. Schebler, acquired from the Dodgers in the three-team deal that sent Todd Frazier to the White Sox in the offseason, doubled to left-center to complete the rally.

Blake Wood (1-0) pitched one inning for the win, the Reds’ seventh straight over the Phillies at Great American Ball Park. Cincinnati has won 10 of its last 11 against Philadelphia there.