BALTIMORE — There was no retaliation by the Red Sox on Saturday night. Baltimore’s Manny Machado had four peaceful at-bats one night after his hard slide into second base knocked Dustin Pedroia out of the game with left knee and ankle injuries.

Perhaps it’s time the Red Sox started retaliating against some baseballs.

With an injured Pedroia watching from the bench, the Sox lacked punch again in a 4-2 loss against the Orioles.

That’s three losses in the last four games for the Sox, who have scored six runs in their last 28 innings. Jayson Aquino, a rookie making his first major league start, combined with three relievers to hold the Sox to six hits.

The Sox are 1 for 16 with runners in scoring position in two games at hitter-friendly Camden Yards. Of their 12 hits, 11 have been singles.

“There’s been a number of times we’ve expanded the [strike] zone,’’ Sox manager John Farrell said. “We’ve chased some pitches down below the zone. We’ve chased some pitches off [and] away.

“That’s kind of what it boils down to. Where we’ve been so good at trusting the next guy behind us in the lineup rather than being the guy in the moment and staying patient with building an inning, staying controlled, staying relentless with our disciplined strike zone, we’ve expanded outside it.’’

Red Sox starter Steven Wright faced the Orioles on April 12 at Fenway Park and had the worst start of career, giving up eight runs on eight hits before being taken out in the second inning. The Orioles hit four home runs off him.

In the rematch, Wright opened the game with three scoreless innings and had a 2-0 lead courtesy of Jackie Bradley Jr.’s long home run in the third inning.

With Xander Bogaerts on first, Bradley got a cutter over the plate from Aquino and drove it 420 feet to right field. The ball cleared the out-of-town scoreboard, a standing-room section, and another fence before coming down on Eutaw Street. It was the 89th time in Camden Yards history a home run landed on the street. Bradley became the fifth Red Sox player to do it, the first since David Ortiz in 2012.

The lead did not last long for the Sox. The Orioles scored four runs on six hits in the fourth inning. Chris Davis doubled to right field off a fastball, beating the defensive shift by going over it. Rookie Trey Mancini then homered to left-center. Jonathan Schoop followed three pitches later with a home run the same way.

Mancini and Schoop also hit back-to-back home runs off Wright on April 12.

With two outs, Caleb Joseph doubled to the gap in right field. He was 0 for 12 on the season before going 2 for 2 against Wright.

Singles by Craig Gentry and Adam Jones scored Joseph and that was it for Wright.

“Mancini hit a ball that went in to him and he crushed it. They hit mistakes and that’s what makes them good,’’ Wright said.

Wright has made four starts and lasted only 17⅔ innings. The knuckleballer has allowed 17 earned runs on 33 hits, seven of them home runs.

“They’re pretty large totals,’’ Farrell said. “I will say this: I thought tonight the way the game got underway, he’s in pretty good shape. I thought he executed a number of quality pitches.’’

Wright said his knuckleball hasn’t been consistent.

“It’s something I’ve definitely been aware of and am working on, to get the violence back to the pitch,’’ he said.

Wright was 13-6 with a 3.33 earned run average last season, making the All-Star team. But since injuring his shoulder last season, Wright has an 8.45 earned run average in six starts and opponents have hit .392 against him.

Wright said his shoulder feels strong and that his issues are related to how he releases the ball.

“I feel good. That’s probably the most frustrating thing is I worked so hard this offseason to get my shoulder back to 100 percent. I feel it’s just a matter of getting muscle memory back and getting back to where I was before the injury,’’ he said.

“It’s one of those things that’s really frustrating because I feel strong. This is the first time I’ve struggled like this. It’s definitely depressing going out there and putting such a burden on the bullpen. You get a 2-0 lead and you go out there give up a four-spot, that’s never good.’’

Heath Hembree kept the Sox in the game, working 3⅓ innings of scoreless relief. He struck out five.

The Sox (10-8) will try to avoid a three-game sweep when they send Eduardo Rodriguez to the mound against Kevin Gausman. The Orioles have won four straight and are 3-1 against the Sox this season.

Peter Abraham can be reached at pabraham@globe.com. Follow him on Twitter @PeteAbe.